Loading…
A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH
This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the values and variability in these parameters; and present quantitative meta-models of distributions of GI pH to...
Saved in:
Published in: | The AAPS journal 2016-09, Vol.18 (5), p.1309-1321 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c480t-f4b20df689997af17f26fb69c26e317f37bc26ae1b0e9ce0e07867e3ed5650de3 |
---|---|
cites | cdi_FETCH-LOGICAL-c480t-f4b20df689997af17f26fb69c26e317f37bc26ae1b0e9ce0e07867e3ed5650de3 |
container_end_page | 1321 |
container_issue | 5 |
container_start_page | 1309 |
container_title | The AAPS journal |
container_volume | 18 |
creator | Abuhelwa, Ahmad Y. Foster, David J. R. Upton, Richard N. |
description | This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the values and variability in these parameters; and present quantitative meta-models of distributions of GI pH to help inform models of oral drug absorption. The literature was systemically reviewed for the values of, and the variability in, GI pH under fed and fasted conditions. The GI tract was categorized into the following 10 distinct regions: stomach (proximal, mid-distal), duodenum (proximal, mid-distal), jejunum and ileum (proximal, mid, and distal small intestine), and colon (ascending, transverse, and descending colon). Meta-analysis used the “metafor” package of the R language. The time course of postprandial stomach pH was modeled using NONMEM. Food significantly influenced the estimated meta-mean stomach and duodenal pH but had no significant influence on small intestinal and colonic pH. The time course of postprandial pH was described using an exponential model. Increased meal caloric content increased the extent and duration of postprandial gastric pH buffering. The different parts of the small intestine had significantly different pH. Colonic pH was significantly different for descending but not for ascending and transverse colon. Knowledge of GI pH is important for the formulation design of the pH-dependent dosage forms and in understanding the dissolution and absorption of orally administered drugs. The meta-models of GI pH may also be used as part of semi-physiological pharmacokinetic models to characterize the effect of GI pH on the
in vivo
drug release and pharmacokinetics. |
doi_str_mv | 10.1208/s12248-016-9952-8 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1814134866</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1814134866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-f4b20df689997af17f26fb69c26e317f37bc26ae1b0e9ce0e07867e3ed5650de3</originalsourceid><addsrcrecordid>eNp9kEtOwzAQhi0EouVxADbISzYB20kch11VnhKIh4Ct5STjYpTGxXaK2MEdOCEnwVBArFjNjOabf6QPoS1KdikjYs9TxjKREMqTssxZIpbQkOY5SYqM8uU__QCtef9ASMpSSlfRgBVZmceIIXod4atedcEEFcwc8DXMDTxh1TX4HIJKzm0DrcdW43AP-E45oyrTmvD8hRypOljn8UhrqIPpJvjCqRYfuH6CR5W3bhaM7d5f3i6VC_h0Hx8rH5w1XQAf8YjOTjbQilath83vuo5ujw5vxifJ2cXx6Xh0ltSZICHRWcVIo7koy7JQmhaacV3xsmYc0jilRRVbBbQiUNZAgBSCF5BCk_OcNJCuo51F7szZxz7-l1Pja2hb1YHtvaSCZjTNBOcRpQu0dtZ7B1rOnJkq9ywpkZ_m5cK8jOblp3kp4s32d3xfTaH5vfhRHQG2AHxcdRNw8sH2Ljrw_6R-ACjGkH8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1814134866</pqid></control><display><type>article</type><title>A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH</title><source>PubMed Central Free</source><source>Springer Nature</source><creator>Abuhelwa, Ahmad Y. ; Foster, David J. R. ; Upton, Richard N.</creator><creatorcontrib>Abuhelwa, Ahmad Y. ; Foster, David J. R. ; Upton, Richard N.</creatorcontrib><description>This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the values and variability in these parameters; and present quantitative meta-models of distributions of GI pH to help inform models of oral drug absorption. The literature was systemically reviewed for the values of, and the variability in, GI pH under fed and fasted conditions. The GI tract was categorized into the following 10 distinct regions: stomach (proximal, mid-distal), duodenum (proximal, mid-distal), jejunum and ileum (proximal, mid, and distal small intestine), and colon (ascending, transverse, and descending colon). Meta-analysis used the “metafor” package of the R language. The time course of postprandial stomach pH was modeled using NONMEM. Food significantly influenced the estimated meta-mean stomach and duodenal pH but had no significant influence on small intestinal and colonic pH. The time course of postprandial pH was described using an exponential model. Increased meal caloric content increased the extent and duration of postprandial gastric pH buffering. The different parts of the small intestine had significantly different pH. Colonic pH was significantly different for descending but not for ascending and transverse colon. Knowledge of GI pH is important for the formulation design of the pH-dependent dosage forms and in understanding the dissolution and absorption of orally administered drugs. The meta-models of GI pH may also be used as part of semi-physiological pharmacokinetic models to characterize the effect of GI pH on the
in vivo
drug release and pharmacokinetics.</description><identifier>ISSN: 1550-7416</identifier><identifier>EISSN: 1550-7416</identifier><identifier>DOI: 10.1208/s12248-016-9952-8</identifier><identifier>PMID: 27495120</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Administration, Oral ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Gastrointestinal Tract - drug effects ; Gastrointestinal Tract - metabolism ; Gastrointestinal Transit - drug effects ; Gastrointestinal Transit - physiology ; Humans ; Intestinal Absorption - drug effects ; Intestinal Absorption - physiology ; Pharmaceutical Preparations - administration & dosage ; Pharmaceutical Preparations - metabolism ; Pharmacology/Toxicology ; Pharmacy ; Research Article</subject><ispartof>The AAPS journal, 2016-09, Vol.18 (5), p.1309-1321</ispartof><rights>American Association of Pharmaceutical Scientists 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-f4b20df689997af17f26fb69c26e317f37bc26ae1b0e9ce0e07867e3ed5650de3</citedby><cites>FETCH-LOGICAL-c480t-f4b20df689997af17f26fb69c26e317f37bc26ae1b0e9ce0e07867e3ed5650de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27495120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abuhelwa, Ahmad Y.</creatorcontrib><creatorcontrib>Foster, David J. R.</creatorcontrib><creatorcontrib>Upton, Richard N.</creatorcontrib><title>A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH</title><title>The AAPS journal</title><addtitle>AAPS J</addtitle><addtitle>AAPS J</addtitle><description>This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the values and variability in these parameters; and present quantitative meta-models of distributions of GI pH to help inform models of oral drug absorption. The literature was systemically reviewed for the values of, and the variability in, GI pH under fed and fasted conditions. The GI tract was categorized into the following 10 distinct regions: stomach (proximal, mid-distal), duodenum (proximal, mid-distal), jejunum and ileum (proximal, mid, and distal small intestine), and colon (ascending, transverse, and descending colon). Meta-analysis used the “metafor” package of the R language. The time course of postprandial stomach pH was modeled using NONMEM. Food significantly influenced the estimated meta-mean stomach and duodenal pH but had no significant influence on small intestinal and colonic pH. The time course of postprandial pH was described using an exponential model. Increased meal caloric content increased the extent and duration of postprandial gastric pH buffering. The different parts of the small intestine had significantly different pH. Colonic pH was significantly different for descending but not for ascending and transverse colon. Knowledge of GI pH is important for the formulation design of the pH-dependent dosage forms and in understanding the dissolution and absorption of orally administered drugs. The meta-models of GI pH may also be used as part of semi-physiological pharmacokinetic models to characterize the effect of GI pH on the
in vivo
drug release and pharmacokinetics.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Gastrointestinal Tract - drug effects</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Gastrointestinal Transit - drug effects</subject><subject>Gastrointestinal Transit - physiology</subject><subject>Humans</subject><subject>Intestinal Absorption - drug effects</subject><subject>Intestinal Absorption - physiology</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Research Article</subject><issn>1550-7416</issn><issn>1550-7416</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kEtOwzAQhi0EouVxADbISzYB20kch11VnhKIh4Ct5STjYpTGxXaK2MEdOCEnwVBArFjNjOabf6QPoS1KdikjYs9TxjKREMqTssxZIpbQkOY5SYqM8uU__QCtef9ASMpSSlfRgBVZmceIIXod4atedcEEFcwc8DXMDTxh1TX4HIJKzm0DrcdW43AP-E45oyrTmvD8hRypOljn8UhrqIPpJvjCqRYfuH6CR5W3bhaM7d5f3i6VC_h0Hx8rH5w1XQAf8YjOTjbQilath83vuo5ujw5vxifJ2cXx6Xh0ltSZICHRWcVIo7koy7JQmhaacV3xsmYc0jilRRVbBbQiUNZAgBSCF5BCk_OcNJCuo51F7szZxz7-l1Pja2hb1YHtvaSCZjTNBOcRpQu0dtZ7B1rOnJkq9ywpkZ_m5cK8jOblp3kp4s32d3xfTaH5vfhRHQG2AHxcdRNw8sH2Ljrw_6R-ACjGkH8</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Abuhelwa, Ahmad Y.</creator><creator>Foster, David J. R.</creator><creator>Upton, Richard N.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH</title><author>Abuhelwa, Ahmad Y. ; Foster, David J. R. ; Upton, Richard N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-f4b20df689997af17f26fb69c26e317f37bc26ae1b0e9ce0e07867e3ed5650de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Gastrointestinal Tract - drug effects</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Gastrointestinal Transit - drug effects</topic><topic>Gastrointestinal Transit - physiology</topic><topic>Humans</topic><topic>Intestinal Absorption - drug effects</topic><topic>Intestinal Absorption - physiology</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abuhelwa, Ahmad Y.</creatorcontrib><creatorcontrib>Foster, David J. R.</creatorcontrib><creatorcontrib>Upton, Richard N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The AAPS journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abuhelwa, Ahmad Y.</au><au>Foster, David J. R.</au><au>Upton, Richard N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH</atitle><jtitle>The AAPS journal</jtitle><stitle>AAPS J</stitle><addtitle>AAPS J</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>18</volume><issue>5</issue><spage>1309</spage><epage>1321</epage><pages>1309-1321</pages><issn>1550-7416</issn><eissn>1550-7416</eissn><abstract>This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the values and variability in these parameters; and present quantitative meta-models of distributions of GI pH to help inform models of oral drug absorption. The literature was systemically reviewed for the values of, and the variability in, GI pH under fed and fasted conditions. The GI tract was categorized into the following 10 distinct regions: stomach (proximal, mid-distal), duodenum (proximal, mid-distal), jejunum and ileum (proximal, mid, and distal small intestine), and colon (ascending, transverse, and descending colon). Meta-analysis used the “metafor” package of the R language. The time course of postprandial stomach pH was modeled using NONMEM. Food significantly influenced the estimated meta-mean stomach and duodenal pH but had no significant influence on small intestinal and colonic pH. The time course of postprandial pH was described using an exponential model. Increased meal caloric content increased the extent and duration of postprandial gastric pH buffering. The different parts of the small intestine had significantly different pH. Colonic pH was significantly different for descending but not for ascending and transverse colon. Knowledge of GI pH is important for the formulation design of the pH-dependent dosage forms and in understanding the dissolution and absorption of orally administered drugs. The meta-models of GI pH may also be used as part of semi-physiological pharmacokinetic models to characterize the effect of GI pH on the
in vivo
drug release and pharmacokinetics.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27495120</pmid><doi>10.1208/s12248-016-9952-8</doi><tpages>13</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1550-7416 |
ispartof | The AAPS journal, 2016-09, Vol.18 (5), p.1309-1321 |
issn | 1550-7416 1550-7416 |
language | eng |
recordid | cdi_proquest_miscellaneous_1814134866 |
source | PubMed Central Free; Springer Nature |
subjects | Administration, Oral Animals Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Gastrointestinal Tract - drug effects Gastrointestinal Tract - metabolism Gastrointestinal Transit - drug effects Gastrointestinal Transit - physiology Humans Intestinal Absorption - drug effects Intestinal Absorption - physiology Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - metabolism Pharmacology/Toxicology Pharmacy Research Article |
title | A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A19%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Quantitative%20Review%20and%20Meta-Models%20of%20the%20Variability%20and%20Factors%20Affecting%20Oral%20Drug%20Absorption%E2%80%94Part%20I:%20Gastrointestinal%20pH&rft.jtitle=The%20AAPS%20journal&rft.au=Abuhelwa,%20Ahmad%20Y.&rft.date=2016-09-01&rft.volume=18&rft.issue=5&rft.spage=1309&rft.epage=1321&rft.pages=1309-1321&rft.issn=1550-7416&rft.eissn=1550-7416&rft_id=info:doi/10.1208/s12248-016-9952-8&rft_dat=%3Cproquest_cross%3E1814134866%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c480t-f4b20df689997af17f26fb69c26e317f37bc26ae1b0e9ce0e07867e3ed5650de3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1814134866&rft_id=info:pmid/27495120&rfr_iscdi=true |