Liquid-Infused Poly(styrene‑b‑isobutylene‑b‑styrene) Microfiber Coating Prevents Bacterial Attachment and Thrombosis

Infection and thrombosis associated with medical implants cause significant morbidity and mortality worldwide. As we know, current technologies to prevent infection and thrombosis may cause severe side effects. To overcome these complications without using antimicrobial and anticoagulant drugs, we a...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2016-08, Vol.8 (33), p.21214-21220
Main Authors: Yuan, Shuaishuai, Li, Zhibo, Song, Lingjie, Shi, Hengchong, Luan, Shifang, Yin, Jinghua
Format: Article
Language:English
Subjects:
Blood Coagulation
Coated Materials, Biocompatible
Humans
Lubricants
Styrenes - chemistry
Thrombosis
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Summary:Infection and thrombosis associated with medical implants cause significant morbidity and mortality worldwide. As we know, current technologies to prevent infection and thrombosis may cause severe side effects. To overcome these complications without using antimicrobial and anticoagulant drugs, we attempt to prepare a liquid-infused poly­(styrene-b-isobutylene-b-styrene) (SIBS) microfiber coating, which can be directly coated onto medical devices. Notably, the SIBS microfiber was fabricated through solution blow spinning. Compared to electrospinning, the solution blow spinning method is faster and less expensive, and it is easy to spray fibers onto different targets. The lubricating liquids then wick into and strongly adhere the microfiber coating. These slippery coatings can effectively suppress blood cell adhesion, reduce hemolysis, and inhibit blood coagulation in vitro. In addition, Pseudomonas aeruginosa (P. aeruginosa) on the lubricant infused coatings slides readily, and no visible residue is left after tilting. We furthermore confirm that the lubricants have no effects on bacterial growth. The slippery coatings are also not cytotoxic to L929 cells. This liquid-infused SIBS microfiber coating could reduce the infection and thrombosis of medical devices, thus benefiting human health.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.6b06407