Hypovitaminosis D in Children with Hashimoto’s Thyroiditis

• Published in: Revista medíca de Chile 2016-05, Vol.144 (5), p.611-616
• Main Authors: Sönmezgöz, Ergün, Ozer, Samet, Yilmaz, Resul, Önder, Yalçın, Bütün, Ilknur, Bilge, Serap
• Format: Article
• Language: eng ; spa
• Subjects: 25-Hydroxyvitamin D 2 - blood; Autoantibodies - blood; Autoantibodies - immunology; Case-Control Studies; Child; Female; Hashimoto Disease - blood; Hashimoto Disease - complications; Humans; Iodide Peroxidase - blood; Iodide Peroxidase - immunology; Male; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - diagnosis
• ISSN: 0034-9887; 0717-6163
• DOI: 10.4067/S0034-98872016000500009

Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases. To measure vitamin D levels in children with Hashimoto’s thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls. We included 68 children with HT aged 12 ± 4 years (39 females) from a pediatric outpatient clinic and 68 healthy children aged 10 ± 4 years (37 females). Calcium metabolism parameters, thyroid function tests and anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and 25 hydroxy vitamin D (25OHD) levels were measured. Patients were older than controls but well matched by gender distribution. Mean 25OHD levels were significantly lower in HT patients than controls (16.8 ± 9.3 and 24.1 ± 9.4 ng/mL respectively, P < 0.01). Frequency of vitamin D deficiency was 76 and 35% in HT patients and controls, respectively (P < 0.001). Vitamin D deficiency is more common in children with HT than healthy controls.