Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients

• Published in: International Journal of Obesity 2001-08, Vol.25 (8), p.1101-1107
• Main Authors: NAM, S. Y, KIM, K. R, CHA, B. S, SONG, Y. D, LIM, S. K, LEE, H. C, HUH, K. B
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Body composition; Body fat; Body mass index; Body weight; Diabetes; Diabetes. Impaired glucose tolerance; Diet; Dietary restrictions; Drug dosages; Endocrine pancreas. Apud cells (diseases); Endocrinology; Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose; Growth hormones; Insulin resistance; Medical imaging; Medical sciences; Musculoskeletal system; Obesity; Proteins
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0801636

OBJECTIVE:: To evaluate the effects of low-dose growth hormone (GH) therapy combined with diet restriction on changes in body composition and the consequent change in insulin resistance in newly-diagnosed obese type 2 diabetic patients. DESIGN:: Double-blind and placebo-controlled trial of 25-kcal/kg IBW diet daily with GH (n = 9; rhGH, 0.15 IU/kg body weight/week) or placebo (n = 9) for 12 weeks. SUBJECTS:: Eighteen newly-diagnosed obese type 2 diabetic patients (age 42-56 y, body mass index 28.1±2.7 kg/m2 ). MEASUREMENTS:: Body composition and fat distribution parameters (by bioelectrical impedance analyzer and CT scans), serum IGF-1; serum glucose, insulin and free fatty acid (FFA) during oral glucose tolerance test (OGTT); HbA1c ; serum lipid profiles; and glucose disposal rate (GDR) by euglycemic hyperinsulinemic clamp at baseline and after treatment. RESULTS:: The fraction of body weight lost as fat lost was significantly greater (0.98±0.39 vs 0.52±0.32 kg/kg, P