The Role of Positron Emission Tomography With (68)Gallium (Ga)-Labeled Prostate-specific Membrane Antigen (PSMA) in the Management of Patients With Organ-confined and Locally Advanced Prostate Cancer Prior to Radical Treatment and After Radical Prostatectomy

The role of positron emission tomography (PET) with (68)Gallium (Ga)-labeled prostate-specific membrane antigen (PSMA) imaging for prostate cancer is gaining prominence. Current imaging strategies, despite having progressed significantly, have limitations, in particular their ability to diagnose met...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2016-09, Vol.95, p.11-15
Main Authors: Rai, Bhavan Prasad, Baum, Richard Paul, Patel, Amit, Hughes, Robert, Alonzi, Roberto, Lane, Tim, Adshead, Jim, Vasdev, Nikhil
Format: Article
Language:English
Subjects:
Antigens, Surface
Gallium Radioisotopes
Glutamate Carboxypeptidase II
Humans
Male
Neoplasm Recurrence, Local - diagnostic imaging
Positron-Emission Tomography - methods
Preoperative Care
Prostatectomy
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
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Summary:The role of positron emission tomography (PET) with (68)Gallium (Ga)-labeled prostate-specific membrane antigen (PSMA) imaging for prostate cancer is gaining prominence. Current imaging strategies, despite having progressed significantly, have limitations, in particular their ability to diagnose metastatic lymph node involvement. Preliminary results of PET with (68)Ga-labeled PSMA have shown encouraging results, particularly in the recurrent prostate cancer setting. Furthermore, the ability of PET with (68)Ga-labeled PSMA of playing a dual diagnostic and therapeutic setting (theranostics) is currently being investigated as well. PET with (68)Ga-labeled PSMA certainly has a role to play in bridging some of the voids in contemporary prostate cancer imaging tools.
ISSN:1527-9995
DOI:10.1016/j.urology.2015.12.048