SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer

Highlights • We observed upregulation of SRSF 5–7 proteins in SCLC tissue for the first time. • SRSF 5–7 protein levels in SCLC were higher than in ADC or SQC types of NSCLC. • SRSFs 5–7 detected SCLC in the lung more efficiently than CEA or proGRP. • SRSF5 showed great diagnostic potential for SCLC...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-09, Vol.99, p.57-65
Main Authors: Kim, Hak-Ryul, Lee, Gyeong-Ok, Choi, Keum-Ha, Kim, Dong Kwan, Ryu, Jae-Suk, Hwang, Ki-Eun, Na, Kook-Ju, Choi, Chan, Kuh, Ja Hong, Chung, Myoung Ja, Lee, Mi-Kyoung, So, Hong-Seob, Yoon, Kwon-Ha, Park, Min-Cheol, Na, Kyong-Suk, Kim, Young-Suk, Park, Do-Sim
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor
Carcinoembryonic antigen
Carcinoembryonic Antigen - metabolism
Female
Gene Knockdown Techniques
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Middle Aged
Peptide Fragments - metabolism
Pleural effusion
Pleural Neoplasms - metabolism
Pleural Neoplasms - secondary
Pulmonary/Respiratory
Recombinant Proteins - metabolism
Serine-Arginine Splicing Factors - genetics
Serine-Arginine Splicing Factors - metabolism
Small Cell Lung Carcinoma - metabolism
Small Cell Lung Carcinoma - pathology
Small-cell lung cancer
Splicing factor
SRSF5
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Summary:Highlights • We observed upregulation of SRSF 5–7 proteins in SCLC tissue for the first time. • SRSF 5–7 protein levels in SCLC were higher than in ADC or SQC types of NSCLC. • SRSFs 5–7 detected SCLC in the lung more efficiently than CEA or proGRP. • SRSF5 showed great diagnostic potential for SCLC and extrapulmonary cancer in PE. • SRSF5 is a novel marker for SCLC and extrapulmonary pleural metastatic cancer.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2016.05.018