Antiproliferative Effects of Modified Bioflavonoid in Ex Vivo Model

We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-07, Vol.161 (3), p.381-383
Main Authors: Albegova, D. Z., Kamkina, O. V., Pavlova, S. I., Albegova, Zh. K., Laptev, O. S., Kozlov, I. G.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Proliferation - drug effects
Flavonoids - pharmacology
Immunosuppressive Agents - pharmacology
Internal Medicine
Isoflavones
Laboratory Medicine
Lymphocytes - cytology
Lymphocytes - drug effects
Mice
Mice, Inbred BALB C
Mitogens
Mitogens - pharmacology
Pathology
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Summary:We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens in cell culture. Intraperitoneal injection of modified bioflavonoid and quercetin dihydrate produced a dose-dependent inhibition of proliferation of the in vitro activated splenocytes; modified bioflavonoid demonstrated higher antiproliferative activity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3419-x