High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring

Background Consumption of fructose-rich diets in the United States is on the rise and thought to be associated with obesity and cardiometabolic diseases. Objective We sought to determine the effects of antenatal exposure to high-fructose diet on offspring’s development of metabolic syndrome–like phe...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2016-09, Vol.215 (3), p.378.e1-378.e6
Main Authors: Saad, Antonio F., MD, Dickerson, Joshua, Kechichian, Talar B., MS, Yin, Huaizhi, Gamble, Phyllis, Salazar, Ashley, Patrikeev, Igor, PhD, Motamedi, Massoud, PhD, Saade, George R., MD, Costantine, Maged M., MD
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - analysis
Diet
Fatty Liver - etiology
Female
fructose
Fructose - administration & dosage
Fructose - adverse effects
Glucose Tolerance Test
Hypertension - etiology
Insulin Resistance
Intra-Abdominal Fat - anatomy & histology
Leptin - blood
metabolism
mice
Mice, Inbred C57BL
Obesity - etiology
Obstetrics and Gynecology
offspring
Pregnancy
Prenatal Exposure Delayed Effects
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Summary:Background Consumption of fructose-rich diets in the United States is on the rise and thought to be associated with obesity and cardiometabolic diseases. Objective We sought to determine the effects of antenatal exposure to high-fructose diet on offspring’s development of metabolic syndrome–like phenotype and other cardiovascular disease risk factors later in life. Study Design Pregnant C57BL/6J dams were randomly allocated to fructose solution (10% wt/vol, n = 10) or water (n = 10) as the only drinking fluid from day 1 of pregnancy until delivery. After weaning, pups were started on regular chow, and evaluated at 1 year of life. We measured percent visceral adipose tissue and liver fat infiltrates using computed tomography, and blood pressure using CODA nonivasive monitor. Intraperitoneal glucose tolerance testing with corresponding insulin concentrations were obtained. Serum concentrations of glucose, insulin, triglycerides, total cholesterol, leptin, and adiponectin were measured in duplicate using standardized assays. Fasting homeostatic model assessment was also calculated to assess insulin resistance. P values
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2016.03.038