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Second Primary Lung Cancers Demonstrate Better Survival with Surgery than Radiation
Objective Patients who have had curative surgery for lung cancer are at the highest risk of developing a new lung cancer. Individual studies are usually underpowered to describe the clinical characteristics and outcomes in second primary lung cancer. The goal of this study is to determine which ther...
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Published in: | Seminars in thoracic and cardiovascular surgery 2016, Vol.28 (1), p.195-200 |
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creator | Taioli, Emanuela, MD, PhD Lee, Dong-Seok D, MD Kaufman, Andrew, MD Wolf, Andrea, MD Rosenzweig, Kenneth, MD Gomez, Jorge, MD Flores, Raja M, MD |
description | Objective Patients who have had curative surgery for lung cancer are at the highest risk of developing a new lung cancer. Individual studies are usually underpowered to describe the clinical characteristics and outcomes in second primary lung cancer. The goal of this study is to determine which therapy is best associated with survival in patients who develop a new primary lung cancer. Methods All pathologically proven stage I lung cancer cases that received cancer-directed surgery included in the Surveillance Epidemiology and End Results (SEER) database between 2004 and 2010 were selected. Cases that received radiation therapy were excluded. Cases which developed a second primary lung cancer 6 or more months after the diagnosis of the first cancer were analyzed. The original data set consisted of 9,564 stage I lung cancer cases treated with surgery; 520 of them developed a second primary and completed data were available for 494 of them. Results Stage I disease was diagnosed in 272 patients with second primary lung cancers (58.5%); 45.8% of these underwent cancer surgery alone, 31.6% received radiation alone. Surgery was performed more frequently in early stages and younger patients. Surgical patients had statistically significant longer survival than patients treated with radiation (log-rank p |
doi_str_mv | 10.1053/j.semtcvs.2016.02.010 |
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Individual studies are usually underpowered to describe the clinical characteristics and outcomes in second primary lung cancer. The goal of this study is to determine which therapy is best associated with survival in patients who develop a new primary lung cancer. Methods All pathologically proven stage I lung cancer cases that received cancer-directed surgery included in the Surveillance Epidemiology and End Results (SEER) database between 2004 and 2010 were selected. Cases that received radiation therapy were excluded. Cases which developed a second primary lung cancer 6 or more months after the diagnosis of the first cancer were analyzed. The original data set consisted of 9,564 stage I lung cancer cases treated with surgery; 520 of them developed a second primary and completed data were available for 494 of them. Results Stage I disease was diagnosed in 272 patients with second primary lung cancers (58.5%); 45.8% of these underwent cancer surgery alone, 31.6% received radiation alone. Surgery was performed more frequently in early stages and younger patients. Surgical patients had statistically significant longer survival than patients treated with radiation (log-rank p<0.0001) or not treated with surgery or radiation (log-rank p<0.0001). Conclusions The incidence of second primary lung cancers was 5.4%. Stage I second primaries had improved survival compared to later stage disease and surgery conferred an increased survival benefit as compared to radiation. Ultra-Mini Abstract Previously treated lung cancer patients are at the highest risk of developing a new cancer. Second primary lung cancers are often found in early stage. Surgical resection provides survival benefit to patients with metachronous second primary lung cancer compared to radiation and should be further studied as the treatment of choice.</description><identifier>ISSN: 1043-0679</identifier><identifier>EISSN: 1532-9488</identifier><identifier>DOI: 10.1053/j.semtcvs.2016.02.010</identifier><identifier>PMID: 27568161</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; cancer outcome ; Cancer registry ; cancer treatment ; Cardiothoracic Surgery ; epidemiology ; Female ; Humans ; Lung Neoplasms - mortality ; Lung Neoplasms - radiotherapy ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Neoplasms, Second Primary - mortality ; Neoplasms, Second Primary - radiotherapy ; Neoplasms, Second Primary - surgery ; SEER Program ; Survival Analysis ; United States</subject><ispartof>Seminars in thoracic and cardiovascular surgery, 2016, Vol.28 (1), p.195-200</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-f979a3aee27888dc5efddfe847b67e1ed2e06cf21dc607b29073d0b8223d9c6e3</citedby><cites>FETCH-LOGICAL-c420t-f979a3aee27888dc5efddfe847b67e1ed2e06cf21dc607b29073d0b8223d9c6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27568161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taioli, Emanuela, MD, PhD</creatorcontrib><creatorcontrib>Lee, Dong-Seok D, MD</creatorcontrib><creatorcontrib>Kaufman, Andrew, MD</creatorcontrib><creatorcontrib>Wolf, Andrea, MD</creatorcontrib><creatorcontrib>Rosenzweig, Kenneth, MD</creatorcontrib><creatorcontrib>Gomez, Jorge, MD</creatorcontrib><creatorcontrib>Flores, Raja M, MD</creatorcontrib><title>Second Primary Lung Cancers Demonstrate Better Survival with Surgery than Radiation</title><title>Seminars in thoracic and cardiovascular surgery</title><addtitle>Semin Thorac Cardiovasc Surg</addtitle><description>Objective Patients who have had curative surgery for lung cancer are at the highest risk of developing a new lung cancer. Individual studies are usually underpowered to describe the clinical characteristics and outcomes in second primary lung cancer. The goal of this study is to determine which therapy is best associated with survival in patients who develop a new primary lung cancer. Methods All pathologically proven stage I lung cancer cases that received cancer-directed surgery included in the Surveillance Epidemiology and End Results (SEER) database between 2004 and 2010 were selected. Cases that received radiation therapy were excluded. Cases which developed a second primary lung cancer 6 or more months after the diagnosis of the first cancer were analyzed. The original data set consisted of 9,564 stage I lung cancer cases treated with surgery; 520 of them developed a second primary and completed data were available for 494 of them. Results Stage I disease was diagnosed in 272 patients with second primary lung cancers (58.5%); 45.8% of these underwent cancer surgery alone, 31.6% received radiation alone. Surgery was performed more frequently in early stages and younger patients. Surgical patients had statistically significant longer survival than patients treated with radiation (log-rank p<0.0001) or not treated with surgery or radiation (log-rank p<0.0001). Conclusions The incidence of second primary lung cancers was 5.4%. Stage I second primaries had improved survival compared to later stage disease and surgery conferred an increased survival benefit as compared to radiation. Ultra-Mini Abstract Previously treated lung cancer patients are at the highest risk of developing a new cancer. Second primary lung cancers are often found in early stage. Surgical resection provides survival benefit to patients with metachronous second primary lung cancer compared to radiation and should be further studied as the treatment of choice.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>cancer outcome</subject><subject>Cancer registry</subject><subject>cancer treatment</subject><subject>Cardiothoracic Surgery</subject><subject>epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms, Second Primary - mortality</subject><subject>Neoplasms, Second Primary - radiotherapy</subject><subject>Neoplasms, Second Primary - surgery</subject><subject>SEER Program</subject><subject>Survival Analysis</subject><subject>United States</subject><issn>1043-0679</issn><issn>1532-9488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkU-P1DAMxSMEYpeFjwDqkUuLk7RJegHB8FcaCcTAOcok7m6GNl2SdNB-e1LNwIELJ9vSe7bez4Q8pdBQ6PiLQ5NwyvaYGgZUNMAaoHCPXNKOs7pvlbpfemh5DUL2F-RRSgcARiXnD8kFk51QVNBLstuhnYOrvkQ_mXhXbZdwXW1MsBhT9RanOaQcTcbqDeaMsdot8eiPZqx--XyzTtdYXPnGhOqrcd5kP4fH5MFgxoRPzvWKfH__7tvmY739_OHT5vW2ti2DXA-97A03iEwqpZztcHBuQNXKvZBI0TEEYQdGnRUg96wHyR3sFWPc9VYgvyLPT3tv4_xzwZT15JPFcTQB5yVpqgoMIaFlRdqdpDbOKUUc9O0psKagV576oM889cpTA9OFZ_E9O59Y9hO6v64_AIvg1UmAJejRY9TJeiz4nI9os3az_--Jl_9ssKMP3prxB95hOsxLDIWipjoVg96tT11_SgUAcNrz3_Skn0k</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Taioli, Emanuela, MD, PhD</creator><creator>Lee, Dong-Seok D, MD</creator><creator>Kaufman, Andrew, MD</creator><creator>Wolf, Andrea, MD</creator><creator>Rosenzweig, Kenneth, MD</creator><creator>Gomez, Jorge, MD</creator><creator>Flores, Raja M, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Second Primary Lung Cancers Demonstrate Better Survival with Surgery than Radiation</title><author>Taioli, Emanuela, MD, PhD ; Lee, Dong-Seok D, MD ; Kaufman, Andrew, MD ; Wolf, Andrea, MD ; Rosenzweig, Kenneth, MD ; Gomez, Jorge, MD ; Flores, Raja M, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-f979a3aee27888dc5efddfe847b67e1ed2e06cf21dc607b29073d0b8223d9c6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>cancer outcome</topic><topic>Cancer registry</topic><topic>cancer treatment</topic><topic>Cardiothoracic Surgery</topic><topic>epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms, Second Primary - mortality</topic><topic>Neoplasms, Second Primary - radiotherapy</topic><topic>Neoplasms, Second Primary - surgery</topic><topic>SEER Program</topic><topic>Survival Analysis</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taioli, Emanuela, MD, PhD</creatorcontrib><creatorcontrib>Lee, Dong-Seok D, MD</creatorcontrib><creatorcontrib>Kaufman, Andrew, MD</creatorcontrib><creatorcontrib>Wolf, Andrea, MD</creatorcontrib><creatorcontrib>Rosenzweig, Kenneth, MD</creatorcontrib><creatorcontrib>Gomez, Jorge, MD</creatorcontrib><creatorcontrib>Flores, Raja M, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taioli, Emanuela, MD, PhD</au><au>Lee, Dong-Seok D, MD</au><au>Kaufman, Andrew, MD</au><au>Wolf, Andrea, MD</au><au>Rosenzweig, Kenneth, MD</au><au>Gomez, Jorge, MD</au><au>Flores, Raja M, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Second Primary Lung Cancers Demonstrate Better Survival with Surgery than Radiation</atitle><jtitle>Seminars in thoracic and cardiovascular surgery</jtitle><addtitle>Semin Thorac Cardiovasc Surg</addtitle><date>2016</date><risdate>2016</risdate><volume>28</volume><issue>1</issue><spage>195</spage><epage>200</epage><pages>195-200</pages><issn>1043-0679</issn><eissn>1532-9488</eissn><abstract>Objective Patients who have had curative surgery for lung cancer are at the highest risk of developing a new lung cancer. Individual studies are usually underpowered to describe the clinical characteristics and outcomes in second primary lung cancer. The goal of this study is to determine which therapy is best associated with survival in patients who develop a new primary lung cancer. Methods All pathologically proven stage I lung cancer cases that received cancer-directed surgery included in the Surveillance Epidemiology and End Results (SEER) database between 2004 and 2010 were selected. Cases that received radiation therapy were excluded. Cases which developed a second primary lung cancer 6 or more months after the diagnosis of the first cancer were analyzed. The original data set consisted of 9,564 stage I lung cancer cases treated with surgery; 520 of them developed a second primary and completed data were available for 494 of them. Results Stage I disease was diagnosed in 272 patients with second primary lung cancers (58.5%); 45.8% of these underwent cancer surgery alone, 31.6% received radiation alone. Surgery was performed more frequently in early stages and younger patients. Surgical patients had statistically significant longer survival than patients treated with radiation (log-rank p<0.0001) or not treated with surgery or radiation (log-rank p<0.0001). Conclusions The incidence of second primary lung cancers was 5.4%. Stage I second primaries had improved survival compared to later stage disease and surgery conferred an increased survival benefit as compared to radiation. Ultra-Mini Abstract Previously treated lung cancer patients are at the highest risk of developing a new cancer. Second primary lung cancers are often found in early stage. Surgical resection provides survival benefit to patients with metachronous second primary lung cancer compared to radiation and should be further studied as the treatment of choice.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27568161</pmid><doi>10.1053/j.semtcvs.2016.02.010</doi><tpages>6</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over cancer outcome Cancer registry cancer treatment Cardiothoracic Surgery epidemiology Female Humans Lung Neoplasms - mortality Lung Neoplasms - radiotherapy Lung Neoplasms - surgery Male Middle Aged Neoplasms, Second Primary - mortality Neoplasms, Second Primary - radiotherapy Neoplasms, Second Primary - surgery SEER Program Survival Analysis United States |
title | Second Primary Lung Cancers Demonstrate Better Survival with Surgery than Radiation |
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