Prepubertal Vulvar Fibroma: Neoplasm or Physiological Condition?

Abstract Background Several authors have previously reconsidered vulvar fibroma, a rare prepubertal neoplasm, as a physiological labial asymmetry of early puberty, recommending a conservative approach for all cases, although some required further clarification. Case A fibrous mass found in the left...

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Bibliographic Details
Published in:Journal of pediatric & adolescent gynecology 2016-10, Vol.29 (5), p.e67-e70
Main Authors: Goldrat, Oranite, MD, Lingier, Pierre, MD, Massez, Anne, MD, Noël, Jean-Christophe, MD, PhD
Format: Article
Language:English
Subjects:
Child, Preschool
Diagnosis, Differential
Female
Fibroma - diagnosis
Fibroma - surgery
Hamartoma
Humans
Labial enlargement
Neoplasm
Neoplasm Recurrence, Local - surgery
Obstetrics and Gynecology
Pediatrics
Physiological labium asymmetry
Prepubertal vulvar mass
Vulvar Neoplasms - diagnosis
Vulvar Neoplasms - surgery
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Summary:Abstract Background Several authors have previously reconsidered vulvar fibroma, a rare prepubertal neoplasm, as a physiological labial asymmetry of early puberty, recommending a conservative approach for all cases, although some required further clarification. Case A fibrous mass found in the left labium majus of a 4-year-old girl was surgically removed. Imaging confirmed a relapse after 10 months and a second surgery was performed due to extremely rapid growth. No subsequent relapse occurred after 2 years of follow-up. Diagnosis confirmed prepubertal vulvar fibroma, with positive CD34 and lack of actin, desmin, S100, and estrogen receptors. Summary and Conclusion A diagnosis of prepubertal labial asymmetry should prompt careful consideration of several variables, such as age, and radiologic and histologic features, in order to differentiate between a physiological condition and a neoplasm.
ISSN:1083-3188
1873-4332
DOI:10.1016/j.jpag.2016.02.003