MicroRNA Regulators of Anxiety and Metabolic Disorders

Anxiety-related and metabolic disorders are under intense research focus. Anxiety-induced microRNAs (miRNAs) are emerging as regulators that are not only capable of suppressing inflammation but can also induce metabolic syndrome-related processes. We summarize here evidence linking miRNA pathways wh...

Full description

Saved in:
Bibliographic Details
Published in:Trends in molecular medicine 2016-09, Vol.22 (9), p.798-812
Main Authors: Meydan, Chanan, Shenhar-Tsarfaty, Shani, Soreq, Hermona
Format: Article
Language:English
Subjects:
Acetylcholine - genetics
Acetylcholine - metabolism
Animals
anxiety
Anxiety - complications
Anxiety - genetics
Anxiety - metabolism
cholinergic
Gene Expression Regulation
Humans
Inflammation - complications
Inflammation - genetics
Inflammation - metabolism
Metabolic Diseases - complications
Metabolic Diseases - genetics
Metabolic Diseases - metabolism
metabolic disorder
MicroRNAs - genetics
MicroRNAs - metabolism
miRNAs
obesity
Pathology
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anxiety-related and metabolic disorders are under intense research focus. Anxiety-induced microRNAs (miRNAs) are emerging as regulators that are not only capable of suppressing inflammation but can also induce metabolic syndrome-related processes. We summarize here evidence linking miRNA pathways which share regulatory networks in metabolic and anxiety-related conditions. In particular, miRNAs involved in these disorders include regulators of acetylcholine signaling in the nervous system and their accompanying molecular machinery. These have been associated with anxiety-prone states in individuals, while also acting as inflammatory suppressors. In peripheral tissues, altered miRNA pathways can lead to dysregulated metabolism. Common pathways in metabolic and anxiety-related phenomena might offer an opportunity to reclassify ‘healthy’ and ‘unhealthy’, as well as metabolic and anxiety-prone biological states, and inform putative strategies to treat these disorders.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2016.07.001