Inhibition of skin inflammation by baicalin ultradeformable vesicles

[Display omitted] The topical efficacy of baicalin, a natural flavonoid isolated from Scutellaria baicalensis Georgi, which has several beneficial properties, such as antioxidative, antiviral, anti-inflammatory and antiproliferative, is hindered by its poor aqueous solubility and low skin permeabili...

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Bibliographic Details
Published in:International journal of pharmaceutics 2016-09, Vol.511 (1), p.23-29
Main Authors: Mir-Palomo, Silvia, Nácher, Amparo, Díez-Sales, Octavio, Ofelia Vila Busó, M.A., Caddeo, Carla, Manca, Maria Letizia, Manconi, Maria, Fadda, Anna Maria, Saurí, Amparo Ruiz
Format: Article
Language:English
Subjects:
3T3 Cells
Administration, Cutaneous
Adult
Animals
Baicalin
Cell Survival - drug effects
Cell Survival - physiology
Dermatitis - drug therapy
Dermatitis - metabolism
Dermatitis - pathology
Drug Carriers - administration & dosage
Drug Carriers - metabolism
Female
Flavonoids - administration & dosage
Flavonoids - metabolism
Humans
Mice
Middle Aged
Skin
Skin Absorption - drug effects
Skin Absorption - physiology
Topical delivery
Ultradeformable vesicles
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Summary:[Display omitted] The topical efficacy of baicalin, a natural flavonoid isolated from Scutellaria baicalensis Georgi, which has several beneficial properties, such as antioxidative, antiviral, anti-inflammatory and antiproliferative, is hindered by its poor aqueous solubility and low skin permeability. Therefore, its incorporation into appropriate phospholipid vesicles could be a useful tool to improve its local activity. To this purpose, baicalin at increasing concentrations up to saturation, was incorporated in ultradeformable vesicles, which were small in size (⿼67nm), monodispersed (PI
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2016.06.136