Metabolically healthy obesity is associated with an increased risk of diabetes independently of nonalcoholic fatty liver disease

Objective This study examined whether the metabolically healthy obesity (MHO) phenotype was associated with an increased risk of diabetes in a large cohort of metabolically healthy individuals and whether that association differed by presence of nonalcoholic fatty liver disease (NAFLD). Methods The...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2016-09, Vol.24 (9), p.1996-2003
Main Authors: Chang, Yoosoo, Jung, Hyun‐Suk, Yun, Kyung Eun, Cho, Juhee, Ahn, Jiin, Chung, Eun Chul, Shin, Hocheol, Ryu, Seungho
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Comorbidity
Diabetes Mellitus, Type 2 - epidemiology
Female
Glucose
Health risk assessment
Humans
Incidence
Insulin Resistance
Liver
Male
Metabolic Syndrome - epidemiology
Middle Aged
Non-alcoholic Fatty Liver Disease - epidemiology
Obesity
Obesity, Metabolically Benign - epidemiology
Overweight - epidemiology
Proportional Hazards Models
Republic of Korea
Risk Factors
Waist Circumference
Womens health
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Summary:Objective This study examined whether the metabolically healthy obesity (MHO) phenotype was associated with an increased risk of diabetes in a large cohort of metabolically healthy individuals and whether that association differed by presence of nonalcoholic fatty liver disease (NAFLD). Methods The cohort consisted of 74,509 Korean adults who were metabolically healthy at baseline, defined as not having any metabolic syndrome component except large waist circumference and having homeostasis model assessment of insulin resistance
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21580