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7 tesla T2‐weighted MRI as a tool to improve detection of focal cortical dysplasia

Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI‐visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome. We describe a series of six patients with refractor...

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Bibliographic Details
Published in:Epileptic disorders 2016-09, Vol.18 (3), p.315-323
Main Authors: Veersema, Tim J., van Eijsden, Pieter, Gosselaar, Peter H., Hendrikse, Jeroen, Zwanenburg, Jaco J.M., Spliet, Wim G.M., Aronica, Eleonora, Braun, Kees P.J., Ferrier, Cyrille H.
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Language:English
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Summary:Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI‐visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome. We describe a series of six patients with refractory epilepsy due to histopathologically‐confirmed focal cortical dysplasia, for whom pre‐surgical 7 tesla T2*‐weighted MRI was acquired. In four of six patients, T2* sequences showed areas of marked superficial hypointensity, co‐localizing with the epileptogenic lesion. 7 tesla T2* hypointensities overlying focal cortical dysplasia may represent leptomeningeal venous vascular abnormalities associated with the underlying dysplastic cortex. Adding T2* sequences to the MRI protocol may aid in the detection of focal cortical dysplasias.
ISSN:1294-9361
1950-6945
DOI:10.1684/epd.2016.0838