Genetic polymorphisms of interleukin-22 in patients with ulcerative colitis

Ulcerative colitis (UC) is a multifactorial and polygenic disease. Interleukin-22 (IL-22) is an immunomodulatory cytokine that belongs to the IL-10 family. Currently, some IL-22 polymorphisms have been associated with inflammatory processes such as rheumatoid arthritis and psoriasis vulgaris, but th...

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Bibliographic Details
Published in:Revista de gastroenterología de México 2016-04, Vol.81 (2), p.86-90
Main Authors: Yamamoto-Furusho, J K, Sánchez-Morales, G E, García-Rangel, D, Vargas-Alarcón, G
Format: Article
Language:eng ; spa
Subjects:
Adult
Aged
Colitis, Ulcerative - epidemiology
Colitis, Ulcerative - genetics
DNA - genetics
Female
Gene Frequency
Genotype
Humans
Interleukin-22
Interleukins - genetics
Male
Mexico - epidemiology
Middle Aged
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide
Online Access:Get full text
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Summary:Ulcerative colitis (UC) is a multifactorial and polygenic disease. Interleukin-22 (IL-22) is an immunomodulatory cytokine that belongs to the IL-10 family. Currently, some IL-22 polymorphisms have been associated with inflammatory processes such as rheumatoid arthritis and psoriasis vulgaris, but there are no studies on UC. The aim of this work was to study the frequency of polymorphisms of IL-22 in Mexican patients with UC. We studied a total of 199 Mexican patients with confirmed UC and 697 healthy controls. All individuals were born in Mexico, at least three family generations earlier. A blood sample was obtained from the UC patients and healthy controls in order to perform DNA extraction and then to determine the frequency of IL-22 polymorphisms (rs2227485, rs2272478, rs2227491). No statistical significance was found in the gene and genotype frequencies of three SNPs of IL-22 (rs2227485, rs2272478, rs2227491) between the UC patients and healthy controls. No association was found between those IL-22 SNPs and clinical features of UC. There was no association between IL-22 SNPs (rs2227485, rs2272478, rs2227491) and the development of UC in a Mexican population.
ISSN:0375-0906
DOI:10.1016/j.rgmx.2016.02.002