Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, ames and Umu tests

Two types of chitosan oligosaccharides (COS), COS I (1-kDa < MW < 3-kDa) and COS II (3-kDa < MW < 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosacchar...

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Bibliographic Details
Published in:Biotechnology letters 2001-06, Vol.23 (12), p.971-975
Main Authors: NAM, Kyung-Soo, CHOI, Yong-Ri, SHONE, Yun-Hee
Format: Article
Language:English
Subjects:
Ames test
antimutagenic agents
Bacillus subtilis
Bacteria
Biological and medical sciences
Biotechnology
Chemical mutagenesis
chitosan
Fundamental and applied biological sciences. Psychology
Gene expression
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Medical sciences
Mutagenicity
Mutagens
Mutation
oligosaccharides
Other active biomolecules
Production of active biomolecules
Toxicology
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Summary:Two types of chitosan oligosaccharides (COS), COS I (1-kDa < MW < 3-kDa) and COS II (3-kDa < MW < 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosaccharide dose (1 mg) tested, mutagenic activity of indirect-acting mutagen was inhibited by 50% in the Umu gene expression system and in the Ames test. Chitosan oligosaccharide (0.01, 0.1 and 1 mg) also suppressed 4-nitroquinoline-N-oxide (NQO)-induced mutagenicity in the B. subtilis Rec^sup -^ assay.[PUBLICATION ABSTRACT]
ISSN:0141-5492
1573-6776
DOI:10.1023/A:1010519224254