Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, ames and Umu tests

Two types of chitosan oligosaccharides (COS), COS I (1-kDa < MW < 3-kDa) and COS II (3-kDa < MW < 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosacchar...

Full description

Saved in:
Bibliographic Details
Published in:Biotechnology letters 2001-06, Vol.23 (12), p.971-975
Main Authors: NAM, Kyung-Soo, CHOI, Yong-Ri, SHONE, Yun-Hee
Format: Article
Language:English
Subjects:
Ames test
antimutagenic agents
Bacillus subtilis
Bacteria
Biological and medical sciences
Biotechnology
Chemical mutagenesis
chitosan
Fundamental and applied biological sciences. Psychology
Gene expression
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Medical sciences
Mutagenicity
Mutagens
Mutation
oligosaccharides
Other active biomolecules
Production of active biomolecules
Toxicology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c324t-9367b98627454c07f87ea388dcc12936931f8074df7d497ff93f8be7d1c384413
cites
container_end_page 975
container_issue 12
container_start_page 971
container_title Biotechnology letters
container_volume 23
creator NAM, Kyung-Soo
CHOI, Yong-Ri
SHONE, Yun-Hee
description Two types of chitosan oligosaccharides (COS), COS I (1-kDa < MW < 3-kDa) and COS II (3-kDa < MW < 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosaccharide dose (1 mg) tested, mutagenic activity of indirect-acting mutagen was inhibited by 50% in the Umu gene expression system and in the Ames test. Chitosan oligosaccharide (0.01, 0.1 and 1 mg) also suppressed 4-nitroquinoline-N-oxide (NQO)-induced mutagenicity in the B. subtilis Rec^sup -^ assay.[PUBLICATION ABSTRACT]
doi_str_mv 10.1023/A:1010519224254
format article
fullrecord <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_proquest_miscellaneous_18156132</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18156132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c324t-9367b98627454c07f87ea388dcc12936931f8074df7d497ff93f8be7d1c384413</originalsourceid><addsrcrecordid>eNpdjktLAzEUhYMoWKtrt0HQlaN5TW7SnZT6gIIgduuQZpI2ZR51khH890bsytW93PPdcw5Cl5TcUcL4_cOMEkpKqhkTrBRHaEJL4IUEkMdoQqigRSk0O0VnMe4IIRoITNDH4ss0o0mh73Dvcdo6bLoU2jGZjeuCxfs-uXwwza9styH10WS0CZu8WLs1Q6jdDL85e4tN62J-r_GqHXFyMcVzdOJNE93FYU7R6nHxPn8ulq9PL_OHZWE5E6nQXMJaK8lAlMIS8Aqc4UrV1lKWRc2pVwRE7aEWGrzX3Ku1g5paroSgfIpu_nz3Q_855uSqDdG6pjGd68dYUUVLSTnL4NU_cNePQ5e7VcBLyZQWkKHrA2SiNY0fTGdDrPZDaM3wXVFBJEgJ_AdFNG8P</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>735628947</pqid></control><display><type>article</type><title>Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, ames and Umu tests</title><source>Springer Nature</source><creator>NAM, Kyung-Soo ; CHOI, Yong-Ri ; SHONE, Yun-Hee</creator><creatorcontrib>NAM, Kyung-Soo ; CHOI, Yong-Ri ; SHONE, Yun-Hee</creatorcontrib><description>Two types of chitosan oligosaccharides (COS), COS I (1-kDa &lt; MW &lt; 3-kDa) and COS II (3-kDa &lt; MW &lt; 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosaccharide dose (1 mg) tested, mutagenic activity of indirect-acting mutagen was inhibited by 50% in the Umu gene expression system and in the Ames test. Chitosan oligosaccharide (0.01, 0.1 and 1 mg) also suppressed 4-nitroquinoline-N-oxide (NQO)-induced mutagenicity in the B. subtilis Rec^sup -^ assay.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 0141-5492</identifier><identifier>EISSN: 1573-6776</identifier><identifier>DOI: 10.1023/A:1010519224254</identifier><identifier>CODEN: BILED3</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Ames test ; antimutagenic agents ; Bacillus subtilis ; Bacteria ; Biological and medical sciences ; Biotechnology ; Chemical mutagenesis ; chitosan ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Health. Pharmaceutical industry ; Industrial applications and implications. Economical aspects ; Medical sciences ; Mutagenicity ; Mutagens ; Mutation ; oligosaccharides ; Other active biomolecules ; Production of active biomolecules ; Toxicology</subject><ispartof>Biotechnology letters, 2001-06, Vol.23 (12), p.971-975</ispartof><rights>2002 INIST-CNRS</rights><rights>Kluwer Academic Publishers 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-9367b98627454c07f87ea388dcc12936931f8074df7d497ff93f8be7d1c384413</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=14067667$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>NAM, Kyung-Soo</creatorcontrib><creatorcontrib>CHOI, Yong-Ri</creatorcontrib><creatorcontrib>SHONE, Yun-Hee</creatorcontrib><title>Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, ames and Umu tests</title><title>Biotechnology letters</title><description>Two types of chitosan oligosaccharides (COS), COS I (1-kDa &lt; MW &lt; 3-kDa) and COS II (3-kDa &lt; MW &lt; 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosaccharide dose (1 mg) tested, mutagenic activity of indirect-acting mutagen was inhibited by 50% in the Umu gene expression system and in the Ames test. Chitosan oligosaccharide (0.01, 0.1 and 1 mg) also suppressed 4-nitroquinoline-N-oxide (NQO)-induced mutagenicity in the B. subtilis Rec^sup -^ assay.[PUBLICATION ABSTRACT]</description><subject>Ames test</subject><subject>antimutagenic agents</subject><subject>Bacillus subtilis</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chemical mutagenesis</subject><subject>chitosan</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Health. Pharmaceutical industry</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Medical sciences</subject><subject>Mutagenicity</subject><subject>Mutagens</subject><subject>Mutation</subject><subject>oligosaccharides</subject><subject>Other active biomolecules</subject><subject>Production of active biomolecules</subject><subject>Toxicology</subject><issn>0141-5492</issn><issn>1573-6776</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpdjktLAzEUhYMoWKtrt0HQlaN5TW7SnZT6gIIgduuQZpI2ZR51khH890bsytW93PPdcw5Cl5TcUcL4_cOMEkpKqhkTrBRHaEJL4IUEkMdoQqigRSk0O0VnMe4IIRoITNDH4ss0o0mh73Dvcdo6bLoU2jGZjeuCxfs-uXwwza9styH10WS0CZu8WLs1Q6jdDL85e4tN62J-r_GqHXFyMcVzdOJNE93FYU7R6nHxPn8ulq9PL_OHZWE5E6nQXMJaK8lAlMIS8Aqc4UrV1lKWRc2pVwRE7aEWGrzX3Ku1g5paroSgfIpu_nz3Q_855uSqDdG6pjGd68dYUUVLSTnL4NU_cNePQ5e7VcBLyZQWkKHrA2SiNY0fTGdDrPZDaM3wXVFBJEgJ_AdFNG8P</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>NAM, Kyung-Soo</creator><creator>CHOI, Yong-Ri</creator><creator>SHONE, Yun-Hee</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>7QO</scope></search><sort><creationdate>20010601</creationdate><title>Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, ames and Umu tests</title><author>NAM, Kyung-Soo ; CHOI, Yong-Ri ; SHONE, Yun-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-9367b98627454c07f87ea388dcc12936931f8074df7d497ff93f8be7d1c384413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Ames test</topic><topic>antimutagenic agents</topic><topic>Bacillus subtilis</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Chemical mutagenesis</topic><topic>chitosan</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Health. Pharmaceutical industry</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Medical sciences</topic><topic>Mutagenicity</topic><topic>Mutagens</topic><topic>Mutation</topic><topic>oligosaccharides</topic><topic>Other active biomolecules</topic><topic>Production of active biomolecules</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAM, Kyung-Soo</creatorcontrib><creatorcontrib>CHOI, Yong-Ri</creatorcontrib><creatorcontrib>SHONE, Yun-Hee</creatorcontrib><collection>Pascal-Francis</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>ProQuest_Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Biotechnology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAM, Kyung-Soo</au><au>CHOI, Yong-Ri</au><au>SHONE, Yun-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, ames and Umu tests</atitle><jtitle>Biotechnology letters</jtitle><date>2001-06-01</date><risdate>2001</risdate><volume>23</volume><issue>12</issue><spage>971</spage><epage>975</epage><pages>971-975</pages><issn>0141-5492</issn><eissn>1573-6776</eissn><coden>BILED3</coden><abstract>Two types of chitosan oligosaccharides (COS), COS I (1-kDa &lt; MW &lt; 3-kDa) and COS II (3-kDa &lt; MW &lt; 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosaccharide dose (1 mg) tested, mutagenic activity of indirect-acting mutagen was inhibited by 50% in the Umu gene expression system and in the Ames test. Chitosan oligosaccharide (0.01, 0.1 and 1 mg) also suppressed 4-nitroquinoline-N-oxide (NQO)-induced mutagenicity in the B. subtilis Rec^sup -^ assay.[PUBLICATION ABSTRACT]</abstract><cop>Dordrecht</cop><pub>Springer</pub><doi>10.1023/A:1010519224254</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0141-5492
ispartof Biotechnology letters, 2001-06, Vol.23 (12), p.971-975
issn 0141-5492
1573-6776
language eng
recordid cdi_proquest_miscellaneous_18156132
source Springer Nature
subjects Ames test
antimutagenic agents
Bacillus subtilis
Bacteria
Biological and medical sciences
Biotechnology
Chemical mutagenesis
chitosan
Fundamental and applied biological sciences. Psychology
Gene expression
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Medical sciences
Mutagenicity
Mutagens
Mutation
oligosaccharides
Other active biomolecules
Production of active biomolecules
Toxicology
title Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, ames and Umu tests
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A25%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20antimutagenic%20potential%20of%20chitosan%20oligosaccharide:%20Rec,%20ames%20and%20Umu%20tests&rft.jtitle=Biotechnology%20letters&rft.au=NAM,%20Kyung-Soo&rft.date=2001-06-01&rft.volume=23&rft.issue=12&rft.spage=971&rft.epage=975&rft.pages=971-975&rft.issn=0141-5492&rft.eissn=1573-6776&rft.coden=BILED3&rft_id=info:doi/10.1023/A:1010519224254&rft_dat=%3Cproquest_pasca%3E18156132%3C/proquest_pasca%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c324t-9367b98627454c07f87ea388dcc12936931f8074df7d497ff93f8be7d1c384413%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=735628947&rft_id=info:pmid/&rfr_iscdi=true