Synthesis and quality control of [18F]T807 for tau PET imaging

The detailed synthesis and quality control of [18F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end‐of‐synthesis of over 4.4 TBq/µmole (120 Ci/µmole) and an average radioche...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2016-08, Vol.59 (10), p.411-415
Main Authors: Holt, Daniel P., Ravert, Hayden T., Dannals, Robert F.
Format: Article
Language:English
Subjects:
Carbolines - chemical synthesis
Carbolines - chemistry
Chemistry Techniques, Synthetic
fluorine-18
microwave
PET
Positron-Emission Tomography - methods
Quality Control
Radiochemistry
tau
tau Proteins - metabolism
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Summary:The detailed synthesis and quality control of [18F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end‐of‐synthesis of over 4.4 TBq/µmole (120 Ci/µmole) and an average radiochemical yield of 32%. Compliance with all standard US Pharmacopeia Chapter acceptance tests was observed. The detailed synthesis and quality control of [18F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end‐of‐synthesis of over 4.4 TBq/μmole (120 Ci/μmole) and an average radiochemical yield of 32%. Compliance with all standard USP Chapter acceptance tests was observed.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.3425