The Gene Network Underlying Hypodontia

Mammalian tooth development is a precise and complicated procedure. Several signaling pathways, such as nuclear factor (NF)–κB and WNT, are key regulators of tooth development. Any disturbance of these signaling pathways can potentially affect or block normal tooth development, and presently, there...

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Bibliographic Details
Published in:Journal of Dental Research 2015-07, Vol.94 (7), p.878-885
Main Authors: Yin, W., Bian, Z.
Format: Article
Language:English
Subjects:
Anodontia - genetics
Apoptosis
Apoptosis - genetics
Cell differentiation
Cell Differentiation - genetics
Cell proliferation
Cell Proliferation - genetics
Dentistry
Disease
Gene Regulatory Networks - genetics
Genes
Genetic counseling
Humans
Kinases
Odontogenesis - genetics
Proteins
Quality of life
Signal transduction
Signal Transduction - genetics
Teeth
Tumor necrosis factor-TNF
Wnt protein
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Summary:Mammalian tooth development is a precise and complicated procedure. Several signaling pathways, such as nuclear factor (NF)–κB and WNT, are key regulators of tooth development. Any disturbance of these signaling pathways can potentially affect or block normal tooth development, and presently, there are more than 150 syndromes and 80 genes known to be related to tooth agenesis. Clarifying the interaction and crosstalk among these genes will provide important information regarding the mechanisms underlying missing teeth. In the current review, we summarize recently published findings on genes related to isolated and syndromic tooth agenesis; most of these genes function as positive regulators of cell proliferation or negative regulators of cell differentiation and apoptosis. Furthermore, we explore the corresponding networks involving these genes in addition to their implications for the clinical management of tooth agenesis. We conclude that this requires further study to improve patients’ quality of life in the future.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034515583999