Low serum omentin levels in the elderly population with Type 2 diabetes and polyneuropathy

Aims To investigate the hypothesis that high serum levels of omentin, an adipokine with anti‐inflammatory, insulin‐sensitizing and cardioprotective properties, may be related to a lower risk of diabetic sensorimotor polyneuropathy. Methods The association between serum omentin level and polyneuropat...

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Published in:Diabetic medicine 2015-11, Vol.32 (11), p.1479-1483
Main Authors: Herder, C., Bongaerts, B. W. C., Ouwens, D. M., Rathmann, W., Heier, M., Carstensen-Kirberg, M., Koenig, W., Thorand, B., Roden, M., Meisinger, C., Ziegler, D.
Format: Article
Language:English
Subjects:
Adiponectin - blood
Aged
Aged, 80 and over
Aging
Biomarkers - blood
Cohort Studies
Cross-Sectional Studies
Cytokines - blood
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetic Neuropathies - blood
Diabetic Neuropathies - epidemiology
Down-Regulation
Female
Follow-Up Studies
Germany - epidemiology
GPI-Linked Proteins - blood
Health Surveys
Humans
Lectins - blood
Male
Polyneuropathies - blood
Polyneuropathies - complications
Polyneuropathies - epidemiology
Risk Factors
Tumor Necrosis Factor-alpha - blood
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Summary:Aims To investigate the hypothesis that high serum levels of omentin, an adipokine with anti‐inflammatory, insulin‐sensitizing and cardioprotective properties, may be related to a lower risk of diabetic sensorimotor polyneuropathy. Methods The association between serum omentin level and polyneuropathy was estimated in people aged 61–82 years with Type 2 diabetes (47 with and 168 without polyneuropathy) from the population‐based KORA F4 study. The presence of clinical diabetic sensorimotor polyneuropathy was defined as bilateral impairment of foot vibration perception and/or foot pressure sensation. Omentin levels were determined by enzyme‐linked immunosorbent assay. Results Serum omentin level was inversely associated with polyneuropathy after adjustment for age, sex, height, waist circumference, hypertension, total cholesterol, smoking, alcohol intake and physical activity [odds ratio 0.45 (95% CI 0.21–0.98); P = 0.043]. Although omentin was positively correlated with adiponectin (r = 0.55, P 
ISSN:0742-3071
1464-5491
DOI:10.1111/dme.12761