Zika virus in the female genital tract

Zika virus infection has been associated with adverse fetal outcomes, including congenital microcephaly, and could lead to pregnancy loss, as was described in a mouse model.1,2 Presence of Zika virus has been shown in amniotic fluid, which suggests that the virus can cross the placental barrier.3 Zi...

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Bibliographic Details
Published in:The Lancet infectious diseases 2016-09, Vol.16 (9), p.1000-1001
Main Authors: Prisant, Nadia, Bujan, Louis, Benichou, Hélène, Hayot, Pierre-Humbert, Pavili, Lynda, Lurel, Sylvia, Herrmann, Cecile, Janky, Eustase, Joguet, Guillaume
Format: Article
Language:English
Subjects:
Adult
Animals
Antiretroviral drugs
Blood
Female
Females
Genitalia, Female - virology
Humans
Infections
Infectious Disease
Infectious diseases
RNA, Viral - genetics
RNA, Viral - isolation & purification
Urine
Vector-borne diseases
Viral infections
Zika virus
Zika Virus - genetics
Zika Virus - isolation & purification
Zika Virus Infection - diagnosis
Zika Virus Infection - virology
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Summary:Zika virus infection has been associated with adverse fetal outcomes, including congenital microcephaly, and could lead to pregnancy loss, as was described in a mouse model.1,2 Presence of Zika virus has been shown in amniotic fluid, which suggests that the virus can cross the placental barrier.3 Zika virus has been isolated from several other body fluids, including blood, urine, saliva, breastmilk, and semen.1 Presence of Zika virus in semen was reported after infection and has been shown to persist even after it is undetectable in blood or urine. [...]no data are available on the presence of Zika virus in the female genital tract. [...]the detection of Zika virus in the female genital tract, its clearance kinetics, and its possible persistence would be of utmost importance in the assessment of woman-to-man sexual transmission of the Zika virus, and it could also help clarify the process of mother-to-child vertical transmission.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(16)30193-1