Implications of Total to High-Density Lipoprotein Cholesterol Ratio Discordance With Alternative Lipid Parameters for Coronary Atheroma Progression and Cardiovascular Events

The total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio may quantify atherogenic lipoproteins beyond low-density lipoprotein cholesterol (LDL-C), non-HDL-C and apolipoprotein B (apoB). We analyzed pooled data from 9 trials involving 4,957 patients with coronary artery disease...

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Bibliographic Details
Published in:The American journal of cardiology 2016-09, Vol.118 (5), p.647-655
Main Authors: Elshazly, Mohamed B., MD, Nicholls, Stephen J., MBBS, PhD, Nissen, Steven E., MD, St. John, Julie, MS, Martin, Seth S., MD, MHS, Jones, Steven R., MD, Quispe, Renato, MD, Stegman, Brian, MD, Kapadia, Samir R., MD, Tuzcu, E. Murat, MD, Puri, Rishi, MBBS, PhD
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Aged
Apolipoproteins
Apolipoproteins - blood
Biomarkers - blood
Body Mass Index
Cardiovascular
Cholesterol
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Clinical trials
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Coronary Artery Disease - drug therapy
Coronary Artery Disease - mortality
Disease Progression
Enzymes
Female
Follow-Up Studies
Heart attacks
Humans
Hypertension
Kaplan-Meier Estimate
Laboratories
Lipids
Lipoproteins, HDL - blood
Low density lipoprotein
Male
Middle Aged
Mortality
Plaque, Atherosclerotic - diagnosis
Predictive Value of Tests
Risk assessment
Risk Factors
Sensitivity analysis
Sensitivity and Specificity
Statins
Studies
Survival analysis
Triglycerides
Ultrasonic imaging
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Summary:The total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio may quantify atherogenic lipoproteins beyond low-density lipoprotein cholesterol (LDL-C), non-HDL-C and apolipoprotein B (apoB). We analyzed pooled data from 9 trials involving 4,957 patients with coronary artery disease undergoing serial intravascular ultrasonography to assess changes in percent atheroma volume (ΔPAV) and 2-year major adverse cardiovascular event (MACE) rates when TC/HDL-C levels were discordant with LDL-C, non-HDL-C, and apoB. Discordance was investigated when lipid levels were stratified by
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.06.021