Cardiac Structure and Function and Frailty in Subjects Aged 85 and 86 Years

Frailty is a biologic syndrome reflecting a state of decreased physiological reserve of increasing importance in cardiovascular disease given the aging of the population. The relation between frailty and indexes of cardiac structure and function remains unclear, particularly in the “oldest old.” The...

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Bibliographic Details
Published in:The American journal of cardiology 2016-09, Vol.118 (5), p.760-764
Main Authors: Leibowitz, David, MD, Jacobs, Jeremy M., MBBS, Gilon, Dan, MD, Lande-Stessman, Irit, MD, Ein-Mor, Eliana, MA, Stessman, Jochanan, MD
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Age groups
Aged, 80 and over
Angina pectoris
Body Mass Index
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Cohort Studies
Confidence intervals
Coronary vessels
Diabetes
Echocardiography - methods
Education
Exercise
Fatigue
Female
Frail Elderly - statistics & numerical data
Frailty
Gender
Heart - diagnostic imaging
Heart - physiopathology
Heart attacks
Heart failure
Hospitalization
Humans
Hypertension
Israel - epidemiology
Longitudinal Studies
Male
Mortality
Multivariate analysis
Population
Studies
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Summary:Frailty is a biologic syndrome reflecting a state of decreased physiological reserve of increasing importance in cardiovascular disease given the aging of the population. The relation between frailty and indexes of cardiac structure and function remains unclear, particularly in the “oldest old.” The objective of this study was to examine the association between cardiac function and frailty in an age-homogenous, community-dwelling population of subjects aged 85 and 86 years. Subjects were recruited at ages 85 to 86 from the Jerusalem Longitudinal Cohort Study that has followed an age-homogenous cohort of Jerusalem residents. Subjects underwent echocardiography at their place of residence with standard assessment of cardiac structure and function. Frailty was defined according to the “phenotype of frailty” including at least 3 of the following: weakness, slowness, low physical activity level, exhaustion, and weight loss; 405 subjects (193 men and 212 women) were enrolled in the study. Subjects defined as frail had significantly lower ejection fraction compared with the non-frail group (53.7 ± 0.09% vs 56.4 ± 0.09%; p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.06.005