HPV prevalence and p16INKa overexpression in non-smoking non-drinking oral cavity cancer patients

Objective Our aim was to compare HPV and p16INK4a (p16) expression and their influence on survival and prognosis in oral cavity squamous cell cancer (OCSCC), between non‐smokers and non‐drinkers (NSND) and smokers and drinkers (SD). Subjects and Methods Patients with OCSCC treated with surgery from...

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Bibliographic Details
Published in:Oral diseases 2016-09, Vol.22 (6), p.517-522
Main Authors: Dediol, E, Sabol, I, Virag, M, Grce, M, Muller, D, Manojlović, S
Format: Article
Language:English
Subjects:
Adult
Aged
Alcohol Drinking
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - virology
Cyclin-Dependent Kinase Inhibitor p16 - analysis
Dentistry
Female
Human papillomavirus
Humans
Laryngeal cancer
Male
Middle Aged
Mouth Neoplasms - chemistry
Mouth Neoplasms - virology
non-drinker
non-smoker
Oral cancer
p16INK4a
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology
Prevalence
Prognosis
Smoking
tongue cancer
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Summary:Objective Our aim was to compare HPV and p16INK4a (p16) expression and their influence on survival and prognosis in oral cavity squamous cell cancer (OCSCC), between non‐smokers and non‐drinkers (NSND) and smokers and drinkers (SD). Subjects and Methods Patients with OCSCC treated with surgery from 2000 to 2010 were included in the study. Patients who did not smoke at all or smoked less than 10 pack per years and did not drink alcohol on a daily basis were considered the NSND group. An equal number of SD were the control group. HPV presence was determined from paraffin‐embedded blocks investigated by PCR analysis. p16 expression was evaluated with immunohistochemistry. Results The NSND group were mostly younger or older female patients with tongue or gingival cancers. p16 expression was significantly more frequent in NSND patients (27% vs 10%). Patients with stronger p16 expression had significantly worse survival, especially for tongue cancers (P = 0.026). In Cox multivariate analysis, both HPV and p16 expression carried a negative prognosis for NSND patients (P = 0.0351 and P = 0.0260). Conclusions NSND are a specific population of OCSCC patients. In contrast to oropharyngeal cancer, HPV and p16 expression in OCSCC are negative predictive factors, especially in NSND patients.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12476