Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis in pediatric osteosarcoma

Background MicroRNA‐214 (miR‐214) expression has been demonstrated to be dysregulated in human malignancies and to play various roles in tumor progression. While previous study of miRNA expression profiling found that it was one of the most upregulated miRNAs in osteosarcoma signature, the potential...

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Bibliographic Details
Published in:Pediatric blood & cancer 2014-02, Vol.61 (2), p.206-210
Main Authors: Wang, Zhigang, Cai, Haikang, Lin, Lijun, Tang, Mingjie, Cai, Haiqing
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers, Tumor - genetics
Bone and Bones - metabolism
Bone and Bones - pathology
Bone Neoplasms - genetics
Bone Neoplasms - mortality
Bone Neoplasms - pathology
Child
Child, Preschool
clinicopathologic features
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Hematology
Humans
Male
microRNA-214
MicroRNAs - genetics
Neoplasm Metastasis
Neoplasm Staging
Oncology
Osteosarcoma - genetics
Osteosarcoma - mortality
Osteosarcoma - pathology
overall survival
pediatric osteosarcoma
Pediatrics
Prognosis
progression-free survival
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Survival Rate
Up-Regulation
Young Adult
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Summary:Background MicroRNA‐214 (miR‐214) expression has been demonstrated to be dysregulated in human malignancies and to play various roles in tumor progression. While previous study of miRNA expression profiling found that it was one of the most upregulated miRNAs in osteosarcoma signature, the potential role of miR‐214 in osteosarcomas has been unclear. Therefore, the aim of this study was to investigate association of miR‐214 expression with clinicopathologic features and prognosis in pediatric patients with osteosarcoma. Procedure Quantitative real‐time reverse transcriptase‐polymerase chain reaction analysis was performed to detect expression levels of miR‐214 in cancerous and noncancerous bone tissues from 92 children treated for primary osteosarcomas. Then, the clinical significance of miR‐214 dysregulation in pediatric osteosarcomas was also determined. Results Compared with noncancerous bone tissues, the expression levels of miR‐214 were significantly upregulated in osteosarcoma tissues (P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.24763