Palliative resection of the primary tumor is associated with improved overall survival in incurable stage IV colorectal cancer: A nationwide population‐based propensity‐score adjusted study in the Netherlands

• Published in: International journal of cancer 2016-11, Vol.139 (9), p.2082-2094
• Main Authors: 't Lam‐Boer, Jorine, Van der Geest, Lydia G., Verhoef, Cees, Elferink, Marloes E., Koopman, Miriam, de Wilt, Johannes H.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Cancer; Cancer surgery; Colorectal cancer; Colorectal Neoplasms - mortality; Colorectal Neoplasms - surgery; Female; Humans; Male; Medical research; metastatic colorectal cancer; Middle Aged; Mortality; Neoplasm Staging; Netherlands; Palliative Care - methods; palliative primary tumor resection; Propensity Score; Proportional Hazards Models; Registries; Surgical outcomes; Survival Analysis; systemic therapy
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.30240

As the value of palliative primary tumor resection in stage IV colorectal cancer (CRC) is still under debate, the purpose of this population‐based study was to investigate if palliative primary tumor resection as the initial treatment after diagnosis was associated with improved overall survival. All patients with stage IV colorectal adenocarcinoma (2008–2011) were selected from the Netherlands Cancer Registry, and patients undergoing treatment with curative intent (i.e., metastasectomy, radiofrequency ablation and/or hyperthermic intraperitoneal chemotherapy), or best supportive care were excluded. After propensity score matching, a multivariable Cox proportional hazard model was performed to determine the association between treatment strategy and mortality. From a total group of 10,371 patients with stage IV CRC, 2,746 patients (26%) underwent an elective palliative resection of the primary tumor, whether or not followed by systemic therapy, and 3,345 patients (32%) were initially treated with palliative systemic therapy. After propensity score matching, median overall survival in these groups was 17.2 months (95% CI 16.3–18.1) and 11.5 months (95% CI 11.0–12.0), respectively. In Cox regression analysis, primary tumor resection was significantly associated with improved overall survival (hazard ratio of death = 0.44 [95% CI 0.35–0.55], p