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A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis
Objective To evaluate comparatively the influence of histopathological features on epithelial dysplasia (ED) and the effectiveness in usage of WHO and binary grading systems in actinic cheilitis (AC). Material and methods Cytological and architectural alterations established by WHO for ED were evalu...
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| Published in: | Oral diseases 2016-09, Vol.22 (6), p.523-529 |
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| container_start_page | 523 |
| container_title | Oral diseases |
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| creator | Câmara, PR Dutra, SN Takahama Júnior, A Fontes, KBFC Azevedo, RS |
| description | Objective
To evaluate comparatively the influence of histopathological features on epithelial dysplasia (ED) and the effectiveness in usage of WHO and binary grading systems in actinic cheilitis (AC).
Material and methods
Cytological and architectural alterations established by WHO for ED were evaluated in 107 cases of AC. Epithelial dysplasia was graded using WHO and binary systems. The comparisons were performed using kappa, chi‐square, and phi coefficient tests (P |
| doi_str_mv | 10.1111/odi.12484 |
| format | article |
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To evaluate comparatively the influence of histopathological features on epithelial dysplasia (ED) and the effectiveness in usage of WHO and binary grading systems in actinic cheilitis (AC).
Material and methods
Cytological and architectural alterations established by WHO for ED were evaluated in 107 cases of AC. Epithelial dysplasia was graded using WHO and binary systems. The comparisons were performed using kappa, chi‐square, and phi coefficient tests (P < 0.05).
Results
Most cases were classified as mild ED (44.5%) in the WHO system and as low risk for malignant transformation (64.5%) in the binary system. There was a positive correlation between WHO and binary systems (k = 0.33; P < 0.0002). Loss of basal cell polarity (P < 0.001) was associated with severity of ED grade in the WHO system. Anisonucleosis (P < 0.0001), nuclear pleomorphism (P < 0.0001), anisocytosis (P = 0.03), cell pleomorphism (P = 0.002) increased nuclear/cytoplasm ratio (P < 0.0001), increased nuclear size (P < 0.0001), increased number of mitotic figures (P = 0.0006), and dyskeratosis (P = 0.008) were associated with severity of ED grade in the binary system.
Conclusions
It seems that usage of binary ED grading system in AC may be more precise because there is correlation between many of cytological and some of architectural microscopic alterations with increased grade of ED.]]></description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.12484</identifier><identifier>PMID: 27029007</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>actinic cheilitis ; Adult ; Aged ; Aged, 80 and over ; binary ; Cell Transformation, Neoplastic ; Cheilitis - pathology ; classification ; Dentistry ; epithelial dysplasia ; Epithelium - pathology ; Female ; Histopathology ; Humans ; Male ; Middle Aged ; Oral diseases ; WHO ; World Health Organization ; Young Adult</subject><ispartof>Oral diseases, 2016-09, Vol.22 (6), p.523-529</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4944-9cc608220fd6fb202ed1d5773d8f6be9535df489f4639a6dbdfe6f5c54b715453</citedby><cites>FETCH-LOGICAL-c4944-9cc608220fd6fb202ed1d5773d8f6be9535df489f4639a6dbdfe6f5c54b715453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27029007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Câmara, PR</creatorcontrib><creatorcontrib>Dutra, SN</creatorcontrib><creatorcontrib>Takahama Júnior, A</creatorcontrib><creatorcontrib>Fontes, KBFC</creatorcontrib><creatorcontrib>Azevedo, RS</creatorcontrib><title>A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description><![CDATA[Objective
To evaluate comparatively the influence of histopathological features on epithelial dysplasia (ED) and the effectiveness in usage of WHO and binary grading systems in actinic cheilitis (AC).
Material and methods
Cytological and architectural alterations established by WHO for ED were evaluated in 107 cases of AC. Epithelial dysplasia was graded using WHO and binary systems. The comparisons were performed using kappa, chi‐square, and phi coefficient tests (P < 0.05).
Results
Most cases were classified as mild ED (44.5%) in the WHO system and as low risk for malignant transformation (64.5%) in the binary system. There was a positive correlation between WHO and binary systems (k = 0.33; P < 0.0002). Loss of basal cell polarity (P < 0.001) was associated with severity of ED grade in the WHO system. Anisonucleosis (P < 0.0001), nuclear pleomorphism (P < 0.0001), anisocytosis (P = 0.03), cell pleomorphism (P = 0.002) increased nuclear/cytoplasm ratio (P < 0.0001), increased nuclear size (P < 0.0001), increased number of mitotic figures (P = 0.0006), and dyskeratosis (P = 0.008) were associated with severity of ED grade in the binary system.
Conclusions
It seems that usage of binary ED grading system in AC may be more precise because there is correlation between many of cytological and some of architectural microscopic alterations with increased grade of ED.]]></description><subject>actinic cheilitis</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>binary</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cheilitis - pathology</subject><subject>classification</subject><subject>Dentistry</subject><subject>epithelial dysplasia</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oral diseases</subject><subject>WHO</subject><subject>World Health Organization</subject><subject>Young Adult</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkTlPHDEYhi2UiCsU_IHIUppQDPiecYk2XBHabRKRzvL4WEzmij0TmH-PNwsUkSLFjb_ieR_58wvAMUanOJ-z3oZTTFjFdsA-FggXqCL8XZ4pZwUn9MceOEjpASFcSkp2wR4pEZEIlftgfQ5N3w466jH8djCNk53hlEK3hnfXK6g7C-vQ6TjDPuoGuiGM964JebRzGhqdgobrqO0mkOY0ujbB0EFtxtAFA829C00YQ_oA3nvdJHf0ch-C75cX3xbXxe3q6mZxflsYJhkrpDEiP54gb4WvCSLOYsvLktrKi9pJTrn1rJKeCSq1sLX1TnhuOKtLzBmnh-Dz1jvE_tfk0qjakIxrGt25fkoKV5gLKTFm_4EiKRDDFGf001_oQz_FLi-yEWLOUVVVmTrZUib2KUXn1RBDm_9OYaQ2RalclPpTVGY_vhinunX2jXxtJgNnW-AxNG7-t0mtvty8KottIuQant4SOv5UoqQlV3fLK7W8_MrZEi3Ukj4DFxSrTg</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Câmara, PR</creator><creator>Dutra, SN</creator><creator>Takahama Júnior, A</creator><creator>Fontes, KBFC</creator><creator>Azevedo, RS</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201609</creationdate><title>A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis</title><author>Câmara, PR ; Dutra, SN ; Takahama Júnior, A ; Fontes, KBFC ; Azevedo, RS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4944-9cc608220fd6fb202ed1d5773d8f6be9535df489f4639a6dbdfe6f5c54b715453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>actinic cheilitis</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>binary</topic><topic>Cell Transformation, Neoplastic</topic><topic>Cheilitis - pathology</topic><topic>classification</topic><topic>Dentistry</topic><topic>epithelial dysplasia</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oral diseases</topic><topic>WHO</topic><topic>World Health Organization</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Câmara, PR</creatorcontrib><creatorcontrib>Dutra, SN</creatorcontrib><creatorcontrib>Takahama Júnior, A</creatorcontrib><creatorcontrib>Fontes, KBFC</creatorcontrib><creatorcontrib>Azevedo, RS</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Câmara, PR</au><au>Dutra, SN</au><au>Takahama Júnior, A</au><au>Fontes, KBFC</au><au>Azevedo, RS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2016-09</date><risdate>2016</risdate><volume>22</volume><issue>6</issue><spage>523</spage><epage>529</epage><pages>523-529</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract><![CDATA[Objective
To evaluate comparatively the influence of histopathological features on epithelial dysplasia (ED) and the effectiveness in usage of WHO and binary grading systems in actinic cheilitis (AC).
Material and methods
Cytological and architectural alterations established by WHO for ED were evaluated in 107 cases of AC. Epithelial dysplasia was graded using WHO and binary systems. The comparisons were performed using kappa, chi‐square, and phi coefficient tests (P < 0.05).
Results
Most cases were classified as mild ED (44.5%) in the WHO system and as low risk for malignant transformation (64.5%) in the binary system. There was a positive correlation between WHO and binary systems (k = 0.33; P < 0.0002). Loss of basal cell polarity (P < 0.001) was associated with severity of ED grade in the WHO system. Anisonucleosis (P < 0.0001), nuclear pleomorphism (P < 0.0001), anisocytosis (P = 0.03), cell pleomorphism (P = 0.002) increased nuclear/cytoplasm ratio (P < 0.0001), increased nuclear size (P < 0.0001), increased number of mitotic figures (P = 0.0006), and dyskeratosis (P = 0.008) were associated with severity of ED grade in the binary system.
Conclusions
It seems that usage of binary ED grading system in AC may be more precise because there is correlation between many of cytological and some of architectural microscopic alterations with increased grade of ED.]]></abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>27029007</pmid><doi>10.1111/odi.12484</doi><tpages>7</tpages></addata></record> |
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| subjects | actinic cheilitis Adult Aged Aged, 80 and over binary Cell Transformation, Neoplastic Cheilitis - pathology classification Dentistry epithelial dysplasia Epithelium - pathology Female Histopathology Humans Male Middle Aged Oral diseases WHO World Health Organization Young Adult |
| title | A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis |
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