Improving maternal vitamin D status promotes prenatal and postnatal skeletal muscle development of pig offspring

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2016-10, Vol.32 (10), p.1144-1152
• Main Authors: Zhou, Hui, M.D, Chen, Yuling, M.D, Lv, Gang, Ph.D, Zhuo, Yong, Ph.D, Lin, Yan, Ph.D, Feng, Bin, Ph.D, Fang, Zhengfeng, Ph.D, Che, Lianqiang, Ph.D, Li, Jian, Ph.D, Xu, Shengyu, Ph.D, Wu, De, Ph.D
• Format: Article
• Language: English
• Subjects: Animal Nutritional Physiological Phenomena; Animals; Artificial insemination; Diet; Dietary fiber; Female; Gastroenterology and Hepatology; Hogs; Male; Maternal Nutritional Physiological Phenomena; Maternal vitamin D; Maternal-Fetal Exchange; Models, Animal; Mothers; Muscle development; Muscle Development - genetics; Muscle Development - physiology; Muscle Proteins - genetics; Muscle, Skeletal - embryology; Muscle, Skeletal - growth & development; Muscle, Skeletal - metabolism; Musculoskeletal system; Offspring; Pregnancy; Pregnancy Complications - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Serum 25 OHD; Sus scrofa; Swine; Transcription factors; Transcription Factors - metabolism; Umbilical cord; Vitamin D; Vitamin D - administration & dosage; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D - metabolism; Vitamin D Deficiency - complications; Vitamin D Deficiency - metabolism; Vitamin deficiency; Weaning
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2016.03.004

Abstract Objective Vitamin D deficiency is a worldwide problem and vitamin D has been implicated with muscle development. However, little is known about the effects of maternal vitamin D status on muscle development of offspring. The aim of this study was to evaluate the effects of improving maternal vitamin D status by dietary 25-hydroxyvitamin D3 (25OHD3 ) supplementation on prenatal and postnatal skeletal muscle development of offspring with pigs as model. Methods Twenty gilts were allocated to a normal vitamin D (ND) dietary group with 50μg/Kg vitamin D3 or a high vitamin D (HD) group with an additional 50μg/Kg 25OHD3 from mating to weaning. Muscle samples were obtained from piglets at birth and weaning. Results Serum 25OHD concentrations were significantly increased in gilts and newborn piglets of HD group compared with those of ND group ( P