Lyciumaside and Lyciumate: A New Diacylglycoside and Sesquiterpene Lactone from Lycium shawii

One new diacylglycoside named lyciumaside (1) and a new sesquiterpene lactone named lyciumate (2) were isolated from Lycium shawii Roem. & Schult. The structures of the two new compounds were elucidated based on 1D‐ (1H‐ and 13C‐NMR and NOE) and 2D‐NMR (COSY, HSQC, and HMBC) spectroscopic techni...

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Published in:Helvetica chimica acta 2016-08, Vol.99 (8), p.632-635
Main Authors: Rehman, Najeeb Ur, Hussain, Hidayat, Al-Riyami, Samia Ahmed, Csuk, René, Khiat, Mohammed, Abbas, Ghulam, Al-Rawahi, Ahmed, Green, Ivan R., Ahmed, Ishtiaq, Al-Harrasi, Ahmed
Format: Article
Language:English
Subjects:
Antioxidant activity
Diacylglycoside
Lycium
Lycium shawii
Natural product
Sesquiterpene lactone
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Summary:One new diacylglycoside named lyciumaside (1) and a new sesquiterpene lactone named lyciumate (2) were isolated from Lycium shawii Roem. & Schult. The structures of the two new compounds were elucidated based on 1D‐ (1H‐ and 13C‐NMR and NOE) and 2D‐NMR (COSY, HSQC, and HMBC) spectroscopic techniques, and mass spectrometry (ESI‐MS). Preliminary evaluations demonstrated lyciumaside (1) possesses strong antioxidant activity with an IC50 = 30 μg/ml (80% inhibition) while it was inactive in α‐glucosidase and urease enzymes assays. Lyciumaside and Lyciumate: A New Diacylglycoside and Sesquiterpene Lactone from Lycium shawii N. U. Rehman, H. Hussain*, S. A. Al‐Riyami, R. Csuk, M. Khiat, G. Abbas, A. Al‐Rawahi, I. R. Green, I. Ahmed, A. Al‐Harrasi*
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201600066