Epidemiology of myasthenia gravis in Northern Portugal: Frequency estimates and clinical epidemiological distribution of cases

ABSTRACT Introduction: In this study we estimated the prevalence, incidence, and mortality of myasthenia gravis (MG) in northern Portugal and characterized the clinical features of the patients identified. Methods: We used 2 data sources: clinical records from the hospitals and pyridostigmine prescr...

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Published in:Muscle & nerve 2016-09, Vol.54 (3), p.413-421
Main Authors: Santos, Ernestina, Coutinho, Ester, Moreira, Isabel, Silva, Ana Martins, Lopes, Dina, Costa, Henrique, Silveira, Fernando, Nadais, Goreti, Morais, Hugo, Martins, João, Branco, Maria Ceu, Veiga, Andreia, Silva, Rosa Santos, Ferreira, Augusto, Sousa, Filipa, Freijo, Marta, Matos, Ilda, André, Rui, Negrão, Luís, Fraga, Carla, Santos, Manuela, Sampaio, Mafalda, Lopes, Carlos, Leite, Maria Isabel, Gonçalves, Guilherme
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Antibodies - blood
Child
Child, Preschool
clinical
Databases, Factual
Epidemiology
Estimates
Female
Humans
incidence
Infant
Infant, Newborn
laboratory
Male
Middle Aged
Mortality
myasthenia gravis
Myasthenia Gravis - blood
Myasthenia Gravis - epidemiology
Neurologic Examination
Portugal
Portugal - epidemiology
Prevalence
Receptor Protein-Tyrosine Kinases - immunology
Receptors, Cholinergic - immunology
Retrospective Studies
Young Adult
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Summary:ABSTRACT Introduction: In this study we estimated the prevalence, incidence, and mortality of myasthenia gravis (MG) in northern Portugal and characterized the clinical features of the patients identified. Methods: We used 2 data sources: clinical records from the hospitals and pyridostigmine prescription registers. Results: On December 31, 2013, we estimated a point prevalence of 111.7 patients per million population. The highest prevalence was observed in the group >65 years of age, especially in men (288.1 per million). During 2013, we estimated an incidence rate of 6.3 per million per year. Among women, the incidence rate was highest in the 15–49‐year age group; in men, incidence increased with age up to 22.1 per million in those >65 years old. The MG‐related mortality rate was 0.5 per million. Conclusions: These figures are in keeping with similar studies and emphasize the importance of diagnosis and management of MG in elderly populations. Muscle Nerve 54: 413–421, 2016
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25068