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Molecular characterization of Staphylococcus aureus isolates causing skin and soft tissue infections in patients from Malakand, Pakistan
Comparatively few studies have been published describing Staphylococcus aureus /MRSA epidemiology in Central Asia including Pakistan. Here, we report the genotyping of Staphylococcus aureus strains (that include both methicillin-susceptible and methicillin-resistant Staphylococcus aureus ) from comm...
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Published in: | European journal of clinical microbiology & infectious diseases 2016-09, Vol.35 (9), p.1541-1547 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Comparatively few studies have been published describing
Staphylococcus aureus
/MRSA epidemiology in Central Asia including Pakistan. Here, we report the genotyping of
Staphylococcus aureus
strains (that include both methicillin-susceptible and methicillin-resistant
Staphylococcus aureus
) from community- and hospital-acquired skin and soft-tissue infections in a tertiary care hospital in the Malakand district of the Khyber Pakhtunkhwa Province of Pakistan. Forty-five isolates of
Staphylococcus aureus
were characterized by microarray hybridization. Twenty isolates (44 %) were MRSA, whereas 22 (49 %) were PVL-positive. Fourteen isolates (31 %) harboured both
mecA
and PVL genes. The dominant clones were CC121-MSSA (
n
= 15, 33 %) and the PVL-positive “Bengal Bay Clone” (ST772-MRSA-V;
n
= 13, 29 %). The PVL-positive CC8-MRSA-IV strain “USA300” was found once. The pandemic ST239-MRSA-III strain was absent, although it has previously been observed in Pakistan. These observations require a re-assessment of schemes for initial antibiotic therapy to cover MRSA and they emphasise the need for a rapid and non-molecular test for PVL. |
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ISSN: | 0934-9723 1435-4373 |
DOI: | 10.1007/s10096-016-2695-8 |