Plasma d-Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease

Increased d-dimer is indicative of a hypercoagulable state and found to be associated with acute coronary syndromes. The present study aimed to evaluate whether plasma d-dimer levels could predict subsequent major clinical events in patients with coronary artery disease (CAD). First, 2209 angiograph...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2016-10, Vol.22 (7), p.633-640
Main Authors: Gong, Ping, Yang, Sheng-Hua, Li, Sha, Luo, Song-Hui, Zeng, Rui-Xiang, Zhang, Yan, Guo, Yuan-Lin, Zhu, Cheng-Gang, Xu, Rui-Xia, Li, Jian-Jun
Format: Article
Language:English
Subjects:
Atherosclerosis
Biomarkers - blood
Cardiovascular disease
Coronary Artery Disease - blood
Coronary vessels
Female
Fibrin Fibrinogen Degradation Products - therapeutic use
Health risk assessment
Humans
Male
Prospective Studies
Risk Factors
Severity of Illness Index
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Summary:Increased d-dimer is indicative of a hypercoagulable state and found to be associated with acute coronary syndromes. The present study aimed to evaluate whether plasma d-dimer levels could predict subsequent major clinical events in patients with coronary artery disease (CAD). First, 2209 angiographic-proven patients with CAD were consecutively enrolled. Then, all patients were subjected to follow up for an average of 18 months (ranged from 14 to 1037 days). The relationships of the plasma d-dimer with the severity of CAD and future clinical outcomes were evaluated. We found that plasma d-dimer was higher in patients with prior myocardial infarction (MI) than that in patients with nonprior MI (P = .006). Multivariate linear regression analysis suggested that the plasma d-dimer was linked to the severity of CAD assessed by Gensini score (β = 0.052, 95% confidence interval [CI]: 1.20-6.84, P = .005) even after adjusting for confounding factors. During the follow-up, 42 patients underwent prespecified outcomes. After adjustment for multiple variables in the Cox regression model, the d-dimer levels remained to be a potential predictor of total outcome (hazard ratio = 1.22, 95% CI: 1.09-1.37, P = .001). Therefore, plasma d-dimer levels appeared to be a useful predictor for the severity of CAD and the subsequent major clinical events.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029616634885