Development of the industrial synthesis of vitamin A

The advances made in chemistry during the last 70 years are excellently illustrated by the development of the industrial synthesis of vitamin A, a diterpene crucial in preventing premature death and visual problems. Arens and van Dorp published the first route in 1946, and critical contributions hav...

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Bibliographic Details
Published in:Tetrahedron 2016-03, Vol.72 (13), p.1645-1652
Main Authors: Parker, Gemma L., Smith, Laura K., Baxendale, Ian R.
Format: Article
Language:English
Subjects:
Arens-van Dorp reaction
Cooperation
Death
Julia Olefination
Scientists
Synthesis
Synthesis (chemistry)
Tetrahedrons
Visual
Vitamin A
Vitamins
Wittig reaction
β-Ionone
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Summary:The advances made in chemistry during the last 70 years are excellently illustrated by the development of the industrial synthesis of vitamin A, a diterpene crucial in preventing premature death and visual problems. Arens and van Dorp published the first route in 1946, and critical contributions have been made by a number of scientists since, benefitting from fruitful collaborations between industry and academia. However, these improvements have been mostly incremental, and the work has been performed by a limited number of companies; as yet, there is still no ‘ideal’ synthesis of vitamin A. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2016.02.029