Synthesis, structures, and insulin-like activity of oxidovanadium(V) complexes derived from 2-chloro-N′-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide

Three new oxidovanadium(V) complexes, [VOLL′] (L = 2-chloro-N′-(3-ethoxy-2hydroxybenzylidene)benzohydrazide, L′ = acetohydroxamate for 1, methylmaltolate for 2, and ethylmaltolate for 3), have been prepared. The complexes have been characterized by physicochemical methods and single-crystal X-ray de...

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Bibliographic Details
Published in:Journal of coordination chemistry 2016-04, Vol.69 (8), p.1371-1379
Main Authors: You, Zhonglu, Zheng, Boyang, Yang, Ting, Liu, Fang, Cheng, Xiao-Shan
Format: Article
Language:English
Subjects:
acetohydroxamate
aroylhydrazone
Blood
Forming
Glucose
insulin-like activity
maltol
Mice
Oxidovanadium complex
Single crystals
Synthesis
Vanadium
X-rays
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Summary:Three new oxidovanadium(V) complexes, [VOLL′] (L = 2-chloro-N′-(3-ethoxy-2hydroxybenzylidene)benzohydrazide, L′ = acetohydroxamate for 1, methylmaltolate for 2, and ethylmaltolate for 3), have been prepared. The complexes have been characterized by physicochemical methods and single-crystal X-ray determination. Vanadium in each complex is coordinated by the NOO donor set of L, the OO donor set of L′, and one oxido, forming octahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mice for two weeks. The biological activities show that the complexes at doses of 10.0 and 20.0 mg V·kg −1 can significantly decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2016.1171856