Transglutaminases and receptor tyrosine kinases

Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinase...

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Bibliographic Details
Published in:Amino acids 2013, Vol.44 (1), p.19-24
Main Authors: Sivaramakrishnan, Manaswini, Shooter, Gary K., Upton, Zee, Croll, Tristan I.
Format: Article
Language:English
Subjects:
Amino acids
Analytical Chemistry
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Cellular
Enzymes
Extracellular Matrix Proteins - physiology
Formations
Humans
Integrins - physiology
Kinases
Life Sciences
Neurobiology
Protein Interaction Maps
Proteomics
Receptor Protein-Tyrosine Kinases - physiology
Receptors
Review Article
Signal Transduction
Signalling
Transglutaminases - physiology
Tyrosine
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Summary:Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling. We cite literature that confirms and suggests the formation of integrin:RTK:transglutaminase complexes and explores the occurrence and functionality of these complexes in a large fraction of the RTK family.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-011-1113-x