Magnetically and Near-Infrared Light-Powered Supramolecular Nanotransporters for the Remote Control of Enzymatic Reactions

Cancer is one of the primary causes of death worldwide. A high‐precision analysis of biomolecular behaviors in cancer cells at the single‐cell level and more effective cancer therapies are urgently required. Here, we describe the development of a magnetically‐ and near infrared light‐triggered optic...

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Bibliographic Details
Published in:Angewandte Chemie 2016-05, Vol.128 (22), p.6586-6591
Main Authors: Chechetka, Svetlana A., Yuba, Eiji, Kono, Kenji, Yudasaka, Masako, Bianco, Alberto, Miyako, Eijiro
Format: Article
Language:eng ; ger
Subjects:
Cancer
Cancer therapies
Carbon
Cellular
Chemistry
Death
I.R. radiation
Infrared analysis
Infrared radiation
Iron
Kohlenstoffnanohörner
Light effects
Liposome
Liposomes
Magnetische Nanopartikel
Medical innovations
Mice
Mortality
Nanoparticles
Nanoroboter
Nanostructure
Optical control
Remote control
State of the art
Technology
Therapy
Wirkstofftransportsysteme
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Summary:Cancer is one of the primary causes of death worldwide. A high‐precision analysis of biomolecular behaviors in cancer cells at the single‐cell level and more effective cancer therapies are urgently required. Here, we describe the development of a magnetically‐ and near infrared light‐triggered optical control method, based on nanorobotics, for the analyses of cellular functions. A new type of nanotransporters, composed of magnetic iron nanoparticles, carbon nanohorns, and liposomes, was synthesized for the spatiotemporal control of cellular functions in cells and mice. Our technology will help to create a new state‐of‐the‐art tool for the comprehensive analysis of “real” biological molecular information at the single‐cell level, and it may also help in the development of innovative cancer therapies. Nanoroboter: Magnetische supramolekulare Nanopartikel‐Kohlenstoffnanohorn‐Liposom‐Nanotransporter wurden entwickelt (siehe Bild) und für die ferngesteuerte Freisetzung von funktionellen Molekülen mittels Magnetfeld und Nahinfrarotlaserlicht genutzt. Die Nanotransporter ermöglichen zielgerichtete enzymatische Reaktionen in Zellen und Mäusen.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201602453