Exploring environment-dependent effects of Pd nanostructures on reactive oxygen species (ROS) using electron spin resonance (ESR) technique: implications for biomedical applications

Recently, because of the great advances in tailoring their shape and structure, palladium nanoparticles (Pd NPs) have been receiving increasing attention in biomedical fields apart from their traditional application as industrial catalysts. When considering the potential uses of Pd NPs in biomedicin...

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Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2015-01, Vol.17 (38), p.24937-24943
Main Authors: Wen, Tao, He, Weiwei, Chong, Yu, Liu, Yi, Yin, Jun-Jie, Wu, Xiaochun
Format: Article
Language:English
Subjects:
Ascorbic Acid - chemistry
Biological
Biomedical materials
Catalysis
Catalysts
Electron Spin Resonance Spectroscopy
Free Radical Scavengers - chemistry
Hydrogen Peroxide - chemistry
Hydrogen-Ion Concentration
Metal Nanoparticles - chemistry
Nanomedicine
Nanoparticles
Nanostructure
Oxidation-Reduction
Palladium
Palladium - chemistry
Reactive Oxygen Species - chemistry
Receiving
Singlet Oxygen - chemistry
Superoxides - chemistry
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Summary:Recently, because of the great advances in tailoring their shape and structure, palladium nanoparticles (Pd NPs) have been receiving increasing attention in biomedical fields apart from their traditional application as industrial catalysts. When considering the potential uses of Pd NPs in biomedicine, their catalytic properties need to be evaluated under physiologically relevant conditions. In this article, we demonstrate that Pd nanostructures (NSs, both commercial Pd NPs and in-house-prepared Au@Pd nanorods) can induce O 2 or &z.rad;OH production depending on pH values in the presence of H 2 O 2 . We observed that O 2 is produced under neutral and alkaline conditions but &z.rad;OH under acidic conditions. We also found that Pd NSs can scavenge superoxide and singlet oxygen, which may provide protection in biological systems. On the other hand, their oxidase-like activity may accelerate the oxidation of ascorbic acid and thus may produce negative biological effects. The presented study will provide useful guidance for designing noble metal nanostructures with desired catalytic and biological properties in biomedical applications. Pd nanostructures can promote the decomposition of H 2 O 2 in a pH-dependent manner and scavenge superoxide and singlet oxygen.
ISSN:1463-9076
1463-9084
DOI:10.1039/c5cp04046a