Effect of different contents of magnetic beads on enzymatic IGZO glucose biosensor

In this letter, the glucose biosensor was based on glucose oxidase (GOx) to catalyze the oxidation of glucose. The weak immobilization strength of GOx would lead to the poor sensing characteristics. In order to enhance immobilization strength of GOx, the magnetic beads (MBs) combined with GOx to for...

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Bibliographic Details
Published in:Materials letters 2016-07, Vol.175, p.241-243
Main Authors: Chou, Jung-Chuan, Chen, Jian-Syun, Liao, Yi-Hung, Lai, Chih-Hsien, Huang, Min-Siang, Wu, Tong-Yu, Zhuang, Bo-Yang, Yan, Siao-Jie, Chou, Hsueh-Tao, Hsu, Chih-Chieh
Format: Article
Language:English
Subjects:
Beads
Biosensors
Glucose
Glucose biosensor
Glucose oxidase
Glucose oxidase (GOx)
Immobilization
Indium
Magnetic beads (MBs)
Optimization
Strength
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Summary:In this letter, the glucose biosensor was based on glucose oxidase (GOx) to catalyze the oxidation of glucose. The weak immobilization strength of GOx would lead to the poor sensing characteristics. In order to enhance immobilization strength of GOx, the magnetic beads (MBs) combined with GOx to form the Nafion-MBs-GOx /indium gallium zinc oxide (IGZO) glucose biosensor. Besides, the glucose biosensor modified by different contents of MBs solution was investigated to obtain optimal content of MBs. The Nafion-MBs-GOx /IGZO glucose biosensor with 1.00ml MBs solution had the optimal average sensitivity and linearity which were 7.390mV/mM and 0.994, respectively. •The MBs combined with GOx in order to improve sensing characteristics.•The average sensitivity of glucose biosensor modified by MBs was 7.390mV/mM.•The glucose biosensor had low standard deviation in glucose concentration.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2016.04.050