A sustainable process for (-)- alpha -bisabolol extraction from Eremanthus erythropappus using supercritical CO sub(2) and ethanol as co-solvent

Supercritical carbon dioxide (sc-CO sub(2)) extraction of Candeia (Eremanthus erythropappus) wood was studied using ethanol as a co-solvent. This tree has a great potential for producing (-)- alpha -bisabolol, an interesting compound for the cosmetic and pharmaceutical industries because of its prop...

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Bibliographic Details
Published in:The Journal of supercritical fluids 2016-04, Vol.110, p.39-46
Main Authors: Queiroz, Alex, Cajaiba, Joao
Format: Article
Language:English
Subjects:
Carbon dioxide
Cosmetics
Dynamical systems
Dynamics
Ethanol
Ethyl alcohol
Extraction
Sustainability
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Summary:Supercritical carbon dioxide (sc-CO sub(2)) extraction of Candeia (Eremanthus erythropappus) wood was studied using ethanol as a co-solvent. This tree has a great potential for producing (-)- alpha -bisabolol, an interesting compound for the cosmetic and pharmaceutical industries because of its properties. Using a Box-Behnken experimental design, the effects of pressure, temperature, extraction time and co-solvent percentage on the global yield were systematically evaluated. Static and dynamic extraction modes were compared. The use of ethanol as co-solvent proved itself fundamental for raising the extracted percentage of the desired compound. Both static and dynamic modes provided extracts with (-)- alpha -bisabolol as the major compound, although dynamic system provided the best extraction yields. In the best experimental condition, an extraction yield equal to 0.74% was achieved, which is much higher than the yields obtained using the standard steam distillation reported in the literature. Pressure showed greater influence in the obtained (-)- alpha -bisabolol percentage by the dynamic mode, while temperature was very important in the static system.
ISSN:0896-8446
DOI:10.1016/j.supflu.2015.12.011