Microelectrode Array Probe for Simultaneous Detection of Glutamate and Local Field Potential during Brain Death

High extracellular potassium could induce depression-like depolarizations, elevations of extracellular glutamate and even neuronal death in brain. To investigate the contribution of high potassium in vivo, microelectrode arrays (MEAs) probe were fabricated and implanted in a rat brain for simultaneo...

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Bibliographic Details
Published in:Fēnxī huàxué 2015-07, Vol.43 (7), p.983-988
Main Authors: WEI, Wen-Jing, SONG, Yi-Lin, FAN, Xin-Yi, ZHANG, Song, WANG, Li, XU, Sheng-Wei, CAI, Xin-Xia
Format: Article
Language:English
Subjects:
Arrays
Brain
Death
Glutamates
In vivo methods and tests
Microelectrodes
Potassium
Surgical implants
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Summary:High extracellular potassium could induce depression-like depolarizations, elevations of extracellular glutamate and even neuronal death in brain. To investigate the contribution of high potassium in vivo, microelectrode arrays (MEAs) probe were fabricated and implanted in a rat brain for simultaneous record of striatal local field potential (LFP) and glutamate concentration. During these multi-modal recordings, the rat brain was exposed to a high potassium solution. It was observed that high potassium elevated extracellular glutamate while suppressing the LFP irreversibly. This is one of the first studies in which a dual-mode MEA probes is applied in vivo for neuronal death. It is concluded that the MEA probes are capable of examining specific spatiotemporal relationships between electrical and chemical signaling in the brain. A multi-modal microelectrode arrays (MEAs) probe were fabricated and implanted in a rat brain for simultaneous record of striatal glutamate and LFP during high potassium caused brain death. Key Words * Micro-electromechanical system * Implantable microelectrode array * Brain death * High potassium * Glutamate * Local field potential
ISSN:0253-3820
DOI:10.1016/S1872-2040(15)60837-4