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Photolytic Protein Aggregates: Versatile Materials for Controlled Release of Active Proteins

Photolytic protein aggregates are developed as a facile and versatile platform for light‐induced release of active proteins. The proteins modified with biotin through a photo‐cleavable linker rapidly form aggregates with streptavidin and biotinylated functional molecules simply by mixing. Light irra...

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Bibliographic Details
Published in:Advanced healthcare materials 2016-05, Vol.5 (9), p.1002-1007
Main Authors: Ishiwatari, Akira, Yamaguchi, Satoshi, Takamori, Satoshi, Yamahira, Shinya, Minamihata, Kosuke, Nagamune, Teruyuki
Format: Article
Language:English
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Summary:Photolytic protein aggregates are developed as a facile and versatile platform for light‐induced release of active proteins. The proteins modified with biotin through a photo‐cleavable linker rapidly form aggregates with streptavidin and biotinylated functional molecules simply by mixing. Light irradiation releases active proteins from the aggregates in high yields, and light‐induced uptake of drug‐modified transferrin into living cells is successfully demonstrated.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201500957