Comprehensive metabolite profiling of Plantaginis Semen using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry coupled with elevated energy technique

Plantaginis Semen is commonly used in traditional medicine to treat edema, hypertension, and diabetes. The commercially available Plantaginis Semen in China mainly comes from three species. To clarify the chemical composition and distinct different species of Plantaginis Semen, we established a meta...

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Bibliographic Details
Published in:Journal of separation science 2016-05, Vol.39 (10), p.1842-1852
Main Authors: Wang, Dandan, Qi, Meng, Yang, Qiming, Tong, Renchao, Wang, Rui, Bligh, S.W. Annie, Yang, Li, Wang, Zhengtao
Format: Article
Language:English
Subjects:
Chromatography
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal - analysis
Elevated energy mass spectrometry
Flavonoids
High performance liquid chromatography
Ionization
Ions
Mass spectrometry
Medicine, Chinese Traditional
Metabolite profiles
Metabolites
Molecular Structure
Plantaginis Semen
Plantago - chemistry
Profiling
Quadrupoles
Scientific imaging
Semen
Spectrometry, Mass, Electrospray Ionization
Tandem Mass Spectrometry
Traditional Chinese medicines
Ultra high performance liquid chromatography
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Summary:Plantaginis Semen is commonly used in traditional medicine to treat edema, hypertension, and diabetes. The commercially available Plantaginis Semen in China mainly comes from three species. To clarify the chemical composition and distinct different species of Plantaginis Semen, we established a metabolite profiling method based on ultra high performance liquid chromatography with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry coupled with elevated energy technique. A total of 108 compounds, including phenylethanoid glycosides, flavonoids, guanidine derivatives, terpenoids, organic acids, and fatty acids, were identified from Plantago asiatica L., P. depressa Willd., and P. major L. Results showed significant differences in chemical components among the three species, particularly flavonoids. This study is the first to provide a comprehensive chemical profile of Plantaginis Semen, which could be involved into the quality control, medication guide, and developing new drug of Plantago seeds.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.201501149