Arabino mycolates from synthetic mycolic acids

The synthesis of single mono-arabino mycolates, important lipid antigens from mycobacteria is described, using structurally defined synthetic mycolic acids. Preliminary assays indicate that these are differentially antigenic to antibodies in the serum of people with active tuberculosis. [Display omi...

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Bibliographic Details
Published in:Tetrahedron 2016-06, Vol.72 (22), p.2849-2857
Main Authors: Mohammed, Mohsin O., Baird, Mark S., Al Dulayymi, Juma'a R., Jones, Alison, Gwenin, Christopher D.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Arabino mycolates
Assaying
Lipids
Mycobacteria
Serums
Synthesis
Tetrahedrons
Tuberculosis
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Description
Summary:The synthesis of single mono-arabino mycolates, important lipid antigens from mycobacteria is described, using structurally defined synthetic mycolic acids. Preliminary assays indicate that these are differentially antigenic to antibodies in the serum of people with active tuberculosis. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2016.03.083