Nanocomposite of bimetallic nanodendrite and reduced graphene oxide as a novel platform for molecular imprinting technology

• Published in: Analytica chimica acta 2016-04, Vol.918, p.77-88
• Main Authors: Patra, Santanu, Roy, Ekta, Madhuri, Rashmi, Sharma, Prashant K.
• Format: Article
• Language: English
• Subjects: Bimetallic nanodendrite; Bimetals; Graphene; Graphite - chemistry; Imprinted sensor; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Molecular Imprinting; Mycobacterium; Nanocomposites; Nanostructure; Oxides - chemistry; Platforms; Pyrazinamide; Real sample analysis; Reduced graphene oxide; Reporting; Reproducibility of Results; Sensors; Silver; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Synthesis; X-Ray Diffraction
• ISSN: 0003-2670; 1873-4324
• DOI: 10.1016/j.aca.2016.02.046

In this present work, for the first time, we are reporting a green synthesis approach for the preparation of vinyl modified reduced graphene oxide-based magnetic and bimetallic (Fe/Ag) nanodendrite (RGO@BMNDs). Herein, the RGO@BMNDs acts as a platform for the synthesis of the pyrazinamide (PZA)-imprinted polymer matrix and used for designing of the electrochemical sensor. We have demonstrated how the change in morphology could affect the electrochemical and magnetic property of nanomaterials and for this the reduced graphene oxide-based bimetallic nanoparticle (Fe/Ag) was also prepared It was found that the combination of graphene and bimetallic nanodendrites shows improvement as well as enhancement in the electrocatalytic activity and adsorption capacity, in comparison to their respective nanoparticles. The application of imprinted-RGO@BMNDs sensor was explored for trace level detection of PZA (Limit of detection = 6.65 pg L−1, S/N = 3), which is a drug used for the cure of Tuberculosis. This is lowest detection limit reported so far for the detection of PZA. The sensor is highly selective, cost-effective, simple and free from any interfering effect. The real time application of the sensor was explored by successful detection of PZA in pharmaceutical and human blood serum, plasma and urine samples. [Display omitted] •For the first time, an imprinted nanodendrite has been prepared for PZA sensing.•The nanodendrite was composed of vinyl modified Fe/Ag bimetal on the RGO sheet.•The imprinted RGO@BMNDs modified sensor shows very high sensitivity for PZA.•The proposed sensor shows LOD = 6.65 pg L−1 the lowest reported value for PZA.•The sensor was applied for the PZA-detection in human sera and pharmaceutical samples.