Copper catalyzed oxidative deamination of Betti bases: an efficient approach for benzoylation/formylation of naphthols and phenols

An efficient route for benzoylation or formylation of naphthols/phenols is developed via oxidative deamination of Betti bases. A copper salt catalyst with TBHP as an oxidant is used. Water is used as a reagent as well as solvent. The reaction proceeds through a regioselective radical pathway. Most i...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (46), p.4552-4559
Main Authors: Deb, Mohit L, Pegu, Choitanya Dev, Borpatra, Paran J, Baruah, Pranjal K
Format: Article
Language:English
Subjects:
Benzoylation
Copper
Naphthol
Pathways
Phenols
Radicals
Reagents
Solvents
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Summary:An efficient route for benzoylation or formylation of naphthols/phenols is developed via oxidative deamination of Betti bases. A copper salt catalyst with TBHP as an oxidant is used. Water is used as a reagent as well as solvent. The reaction proceeds through a regioselective radical pathway. Most importantly, the position of acylation is unambiguous. The method is also applicable to non-hydroxy substrates. A copper-catalyzed benzoylation/formylation of naphthols and phenols via oxidative deamination of Betti bases.
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra04567g