INCREASED INHIBITORY SYNAPTIC ACTIVITY IN THE HIPPOCAMPUS (CA1) OF GENETIC ABSENCE EPILEPSY RATS: RELEVANCE OF KINDLING RESISTANCE

• Published in: Epilepsy research 2016-10, Vol.126, p.70-77
• Main Authors: Çarçak, Nihan, Dileköz, Ergin, Gülhan, Rezzan, Onur, Rüştü, Onat, Filiz Yılmaz, Sara, Yıldırım
• Format: Article
• Language: English
• Subjects: Absence epilepsy; Animals; Basolateral Nuclear Complex - physiopathology; CA1 Region, Hippocampal - physiopathology; Disease Models, Animal; Electric Stimulation; Electrophysiology; Epilepsy, Absence - physiopathology; GABA; GAERS; Genetic Predisposition to Disease; In-vivo; Kindling, Neurologic; Male; Neural Inhibition - physiology; Neurology; Neuronal Plasticity - physiology; Paired-pulse depression; Random Allocation; Rats, Wistar; Synaptic Transmission - physiology
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2016.06.013

Highlights • Kindling resistance was overcome by the administration of supra-threshold stimuli, however reaching stage 5 was still delayed in GAERS compared to Wistar rats. • GAERS displayed a significant increase in hippocampal excitability at stage 2 which is the critical stage for the development of convulsive stages. • The paired-pulse despression (PPD) was more pronounced on Schaffer collaterals-CA1 synapses of control GAERS than that observed in the control Wistar rats, whereas their excitability were similar. • Following kindling, there was a decrease in PPD in the Wistar rats as the kindling progress has advanced, and reached at its highest grade upon achievement of stage 5.