Administration of adipose-derived stem cells enhances vascularity, induces collagen deposition, and dermal adipogenesis in burn wounds

Highlights • ASC delivery increased vascularity and collagen within healing burn wounds. • ASC administration increased adipogenesis within the dermis following burn wounding. • ASCs increased the type III:type I collagen ratio in healing burn wounds.

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Bibliographic Details
Published in:Burns 2016-09, Vol.42 (6), p.1212-1222
Main Authors: Bliley, Jacqueline M, Argenta, Anne, Satish, Latha, McLaughlin, Meghan M, Dees, Aaron, Tompkins-Rhoades, Casey, Marra, Kacey G, Rubin, J. Peter
Format: Article
Language:English
Subjects:
Adipocytes
Adipogenesis
Adipose Tissue - cytology
Adipose-derived stem cell
Animals
Burn wounds
Burns - metabolism
Burns - pathology
Burns - therapy
Collagen
Collagen Type I - metabolism
Collagen Type III - metabolism
Critical Care
Dermis - metabolism
Dermis - pathology
Female
Mice
Mice, Nude
Neovascularization, Physiologic
PPAR gamma - metabolism
Stem Cell Transplantation
Stem Cells - metabolism
Vascularization
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Description
Summary:Highlights • ASC delivery increased vascularity and collagen within healing burn wounds. • ASC administration increased adipogenesis within the dermis following burn wounding. • ASCs increased the type III:type I collagen ratio in healing burn wounds.
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2015.12.007