The association of novel IL-33 polymorphisms with sIL-33 and risk of systemic lupus erythematosus

•Interleukin-33 (IL-33) is a novel cytokine and belongs to IL-1 family.•IL-33 gene was significantly associated with the risk of SLE.•IL-33 gene polymorphism exerts influence on the expression of sIL-33.•Serum IL-33 levels were significantly associated with the risk of SLE.•Serum IL-33 was associate...

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Bibliographic Details
Published in:Molecular immunology 2016-09, Vol.77, p.1-7
Main Authors: Guo, Jing, Xiang, Yang, Peng, You-Fan, Huang, Hua-Tuo, Lan, Yan, Wei, Ye-Sheng
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Asian Continental Ancestry Group - genetics
Blood Sedimentation
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Gene
Genetic Predisposition to Disease - genetics
Genotype
Humans
IL-33
Inflammation
Interleukin-33 - blood
Interleukin-33 - genetics
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - genetics
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism
Polymorphism, Single Nucleotide
Risk Factors
Systemic lupus erythematosus
Young Adult
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Summary:•Interleukin-33 (IL-33) is a novel cytokine and belongs to IL-1 family.•IL-33 gene was significantly associated with the risk of SLE.•IL-33 gene polymorphism exerts influence on the expression of sIL-33.•Serum IL-33 levels were significantly associated with the risk of SLE.•Serum IL-33 was associated with the abnormal changed CRP and ESR. The serum level of IL-33 was upregulated in systemic lupus erythematosus (SLE), which may be used as biomarkers and/or therapeutic targets for SLE. The aim of this study was to investigate the association of four novel polymorphisms of IL-33 with risk of SLE. The study population comprised 540 Chinese individuals, including 257subjects with SLE and 283 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confirmed by sequencing. Serum IL-33 (sIL-33) levels were measured by ELISA. The serum SLE levels were significantly higher in the group of patients with SLE than those in the control group (P
ISSN:0161-5890
1872-9142
DOI:10.1016/j.molimm.2016.07.001