Bone health and vitamin D status in alcoholic liver disease

Alcohol consumption is harmful to many organs and tissues, including bones, and it leads to osteoporosis. Hepatic osteodystrophy is abnormal bone metabolism that has been defined in patients with chronic liver disease (CLD), including osteopenia, osteoporosis, and osteomalacia. Decreased bone densit...

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Bibliographic Details
Published in:Indian journal of gastroenterology 2016-07, Vol.35 (4), p.253-259
Main Authors: Kizilgul, M., Ozcelik, O., Delibasi, T.
Format: Article
Language:English
Subjects:
Bone Density
Bone Density Conservation Agents - therapeutic use
Diphosphonates - therapeutic use
Drug Discovery
Gastroenterology
Hepatology
Humans
Liver - metabolism
Liver Diseases, Alcoholic - complications
Liver Diseases, Alcoholic - metabolism
Medicine
Medicine & Public Health
Osteoporosis - diagnosis
Osteoporosis - etiology
Osteoporosis - metabolism
Osteoporosis - therapy
Review Article
Vitamin D - metabolism
Vitamin D Deficiency - etiology
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Summary:Alcohol consumption is harmful to many organs and tissues, including bones, and it leads to osteoporosis. Hepatic osteodystrophy is abnormal bone metabolism that has been defined in patients with chronic liver disease (CLD), including osteopenia, osteoporosis, and osteomalacia. Decreased bone density in patients with CLD results from decreased bone formation or increased bone resorption. The prevalence of osteopenia in alcoholic liver disease (ALD) patients is between 34 % and 48 %, and the prevalence of osteoporosis is between 11 % and 36 %. Cirrhosis is also a risk factor for osteoporosis. The liver has an important role in vitamin D metabolism. Ninety percent of patients with alcoholic liver cirrhosis have vitamin D inadequacy (
ISSN:0254-8860
0975-0711
DOI:10.1007/s12664-016-0652-1