Maternal deprivation increases 5-HT sub(1A) receptor expression in the CA1 and CA3 areas of senescent Brown Norway rats

Maternally-deprived male Brown Norway rats were classified as non-impaired or impaired according to their performance in the water maze when 3 and 30-32 months old. Age and spatial learning ability did not affect the pattern and density of hippocampal 5-HT sub(1A)-receptor mRNA in mother-reared cont...

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Bibliographic Details
Published in:Brain research 2001-08, Vol.912 (1), p.95-98
Main Authors: Sibug, R M, Oitzl, MS, Workel, JO, de Kloet, ER
Format: Article
Language:English
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Summary:Maternally-deprived male Brown Norway rats were classified as non-impaired or impaired according to their performance in the water maze when 3 and 30-32 months old. Age and spatial learning ability did not affect the pattern and density of hippocampal 5-HT sub(1A)-receptor mRNA in mother-reared control rats. However, senescent maternally-deprived rats with impaired spatial learning ability showed increased expression of 5-HT sub(1A)-receptor mRNA in the hippocampal CA1 (14%) and CA3 (13%) areas but not in the dentate gyrus.
ISSN:0006-8993